Document Detail

Pulmonary responses to heparin-protamine complexes: the effects of age and species.
MedLine Citation:
PMID:  8847332     Owner:  NLM     Status:  MEDLINE    
To test the hypothesis that heparin-protamine complexes (H-P complexes) react with pulmonary intravascular macrophages, we studied the difference in the pulmonary reaction to H-P complexes between goats and rabbits and among different-aged goats. The increases in pulmonary arterial pressure (Ppa) and plasma thromboxane levels (Tx) after injection of H-P complexes (1.2 ml/kg) in goats (delta Ppa = 17 +/- 7.0 mmHg, delta Tx = 17.3 +/- 10.1 ng/ml) were significantly greater than in rabbits (delta Ppa = 0.50 +/- 1.0 mmHg, delta Tx = -0.01 +/- 0.17 ng/ml), the increase in Ppa in adult goats (> 150 days old; delta Ppa = 17 +/- 7.0 mmHg) was about sixfold higher than in newborn goats (1-3 days old; delta Ppa = 2.8 +/- 4.0 mmHg), and the increase in Tx in adult goats (delta Tx = 17.3 +/- 10.1 ng/ml) was significantly greater than those in newborn and young (19 days old) goats (delta Tx = 0.69 +/- 0.48 and 3.60 +/- 0.36 ng/ml, respectively). The pulmonary hemodynamic reaction to H-P complexes is consistent with the concept that the H-P complexes react with pulmonary intravascular macrophages.
T Horiguchi; K Enzan; K Kawamura; M Suzuki
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  80     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1996 Jan 
Date Detail:
Created Date:  1996-10-24     Completed Date:  1996-10-24     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  56-61     Citation Subset:  IM    
Department of Anesthesia, Akita Kumiai Hospital, Japan.
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MeSH Terms
Aging / pathology*
Animals, Newborn
Hemodynamics / drug effects
Lung / cytology,  drug effects*,  ultrastructure
Macrophages, Alveolar / drug effects,  physiology,  ultrastructure
Microscopy, Electron
Pulmonary Circulation / drug effects
Species Specificity
Thromboxane B2 / pharmacology
Reg. No./Substance:
54397-85-2/Thromboxane B2

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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