Document Detail

Pulmonary response of hamsters to fibrous glass: chronic effects of repeated intratracheal instillation with or without benzo[a]pyrene.
MedLine Citation:
PMID:  4042277     Owner:  NLM     Status:  MEDLINE    
Syrian golden hamsters were given intratracheal instillations of glass fibres with or without benzo[a]pyrene suspended in saline, once a fortnight for 52 weeks. The experiment was terminated at week 85. 'Silicotic granulomas' consisting of tightly packed, iron-positive macrophages filled with glass fibres and surrounded by a layer of alveolar epithelial cells were the predominant pulmonary lesion. No mesotheliomas or other tumours of the respiratory tract were observed in hamsters treated with glass fibres alone. There was no indication that glass fibres enhanced the development of respiratory tract tumours induced by benzo[a]pyrene. In hamsters similarly exposed to crocidolite fibres with or without benzo[a]pyrene no mesotheliomas or other respiratory tract tumours were observed either. An explanation for the absence of pulmonary tumours might be that repeated administration of fibres over a period of 52 weeks entails an acute pulmonary reaction after each administration with the implication that the fibres cannot settle down well enough to be able to induce tumours. Another possible explanation is the relatively short duration of the experimental period.
V J Feron; P M Scherrenberg; H R Immel; B J Spit
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Carcinogenesis     Volume:  6     ISSN:  0143-3334     ISO Abbreviation:  Carcinogenesis     Publication Date:  1985 Oct 
Date Detail:
Created Date:  1985-11-20     Completed Date:  1985-11-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8008055     Medline TA:  Carcinogenesis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1495-9     Citation Subset:  IM    
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MeSH Terms
Benzo(a)pyrene / pharmacology*
Granuloma / etiology,  pathology
Lung / drug effects*
Silicosis / etiology*,  pathology
Time Factors
Reg. No./Substance:
1332-21-4/Asbestos; 50-32-8/Benzo(a)pyrene

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