| Pulmonary reperfusion syndrome. | |
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MedLine Citation:
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PMID: 453983 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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"Reperfusion syndrome" of the lung may play a role in the pulmonary edema and hemorrhage that occur following pulmonary embolectomy, cardiopulmonary bypass, and shock. Bioenergetic, metabolic, and ultrastructural studies of canine lungs indicate that ventilated lung tissue could tolerate 5 hours of pulmonary arterial occlusion with minimal damage. However, a 24-hour interruption of pulmonary arterial blood flow produced a significant decrease in the ratio of adenosine triphosphate to adenosine disphosphate, and glycogen, and an increase in tissue lactate. Reperfusion of these lungs resulted in even more pronounced biochemical and ultrastructural deterioration, as well as gross pulmonary edema and hemorrhage. The lesion appears to be similar to the reperfusion damage that occurs in other organs, such as the kidney, and the skeletal and cardiac muscles. |
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Authors:
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D L Modry; R C Chiu |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Annals of thoracic surgery Volume: 27 ISSN: 0003-4975 ISO Abbreviation: Ann. Thorac. Surg. Publication Date: 1979 Mar |
Date Detail:
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Created Date: 1979-08-16 Completed Date: 1979-08-16 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 15030100R Medline TA: Ann Thorac Surg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 206-15 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine Diphosphate
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metabolism Adenosine Triphosphate / metabolism Animals Constriction DNA / metabolism Dogs Glycogen / metabolism Hemorrhage / etiology*, metabolism, pathology Ischemia / complications*, metabolism, pathology Lactates / metabolism Lung / blood supply*, metabolism, ultrastructure Lung Diseases / etiology*, metabolism, pathology Pulmonary Artery Pulmonary Edema / etiology*, metabolism, pathology Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Lactates; 56-65-5/Adenosine Triphosphate; 58-64-0/Adenosine Diphosphate; 9005-79-2/Glycogen; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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