Document Detail

Pulmonary receptor chemosensitivity and the ventilatory response to inhaled CO2 in the turtle.
MedLine Citation:
PMID:  451369     Owner:  NLM     Status:  MEDLINE    
Ventilatory responses of unanesthetized turtles to changes in the intrapulmonary CO2 content of a vascularly isolated and an intact lung were measured during spontaneous breathing. The hyperpnea associated with inhalation of CO2 by the vascularly isolated lung was 19% of that associated with inhalation of CO2 by the intact lung. Transection of the vagus nerve supplying the isolated lung abolished this response. We conclude that both inhibition of pulmonary stretch receptor discharge with increasing levels of FICO2 and a functional increase in central inspiratory volume threshold during hypercapnia contribute to tidal volume increases following CO2 inhalation in normal animals. The major component of the ventilatory response of intact turtles to increasing levels of FICO2, however, was an increase in respiratory frequency. When CO2 was inspired only by the vascularly isolated lung the increase in respiratory frequency was only 21% of that recorded when the same levels of CO2 were inspired by the intact lung. Thus the ventilatory response of turtles to increasing levels of FICO2 is primarily dependent upon concomitant hypercapnia.
W K Milsom; D R Jones
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Respiration physiology     Volume:  37     ISSN:  0034-5687     ISO Abbreviation:  Respir Physiol     Publication Date:  1979 May 
Date Detail:
Created Date:  1979-08-29     Completed Date:  1979-08-29     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0047142     Medline TA:  Respir Physiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  101-7     Citation Subset:  IM    
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MeSH Terms
Carbon Dioxide*
Chemoreceptor Cells / physiology*
Lung / innervation*
Turtles / physiology*
Reg. No./Substance:
124-38-9/Carbon Dioxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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