Document Detail

Pulmonary rapidly adapting receptor stimulation does not increase airway resistance in anesthetized rabbits.
MedLine Citation:
PMID:  10471617     Owner:  NLM     Status:  MEDLINE    
In open-chest artificially ventilated rabbits, removal followed by replacement of positive end-expiratory pressure (PEEP maneuver) favors stimulation of airway rapidly adapting receptors (RARs). The purpose of the present study was to determine whether activation of RARs can cause bronchoconstriction. We measured airway pressure, airflow, and tidal volume, and calculated dynamic lung compliance and total lung resistance. PEEP maneuver increased airway pressure swings (16.4 +/- 4% above control; p = 0.0016) and decreased compliance (to 84.8 +/- 2.8% of control; p = 0.0002) without changing resistance (108.0 +/- 4.4% of control; p = 0.85). On the other hand, the resistance increased greatly (93 +/- 13%, p < 0.01) after intravenous injection of acetylcholine or electrical stimulation of vagal efferents, indicating that our system could detect increases in the resistance. In a separate group, we stimulated RARs by stroking the trachea with a cotton tip (tickling), tickling produced cough, manifested by increased pressure and flow without resistance changing. These changes were abolished after paralysis with succinylcholine. Because we did not detect an increase in airflow resistance during activation of RARs by the PEEP maneuver and tickling, we conclude that increase in resistance may not be an important reflex component of airway RARs.
J Yu; J F Zhang; A M Roberts; L C Collins; E C Fletcher
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of respiratory and critical care medicine     Volume:  160     ISSN:  1073-449X     ISO Abbreviation:  Am. J. Respir. Crit. Care Med.     Publication Date:  1999 Sep 
Date Detail:
Created Date:  1999-10-14     Completed Date:  1999-10-14     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9421642     Medline TA:  Am J Respir Crit Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  906-12     Citation Subset:  AIM; IM; S    
Department of Medicine and Department of Physiology and Biophysics, University of Louisville, Louisville, Kentucky, USA.
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MeSH Terms
Acetylcholine / pharmacology
Airway Resistance / physiology*
Efferent Pathways / physiology
Electric Stimulation
Histamine / pharmacology
Injections, Intravenous
Lung Compliance
Mechanoreceptors / physiology*
Physical Stimulation
Positive-Pressure Respiration
Reflex / physiology
Respiratory Function Tests
Statistics, Nonparametric
Trachea / physiopathology
Vagus Nerve / physiology
Vasodilator Agents / pharmacology
Grant Support
Reg. No./Substance:
0/Vasodilator Agents; 51-45-6/Histamine; 51-84-3/Acetylcholine

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