Document Detail

Pulmonary oxygen toxicity: possible role of ammonia in desorbing lung surfactant.
MedLine Citation:
PMID:  6896816     Owner:  NLM     Status:  MEDLINE    
A porous membrane has been synthesized from a fine-weave cotton fabric carboxylated to simulate the fixed negative charges in the alveolar wall. When this membrane is treated with pulmonary surfactant in physiological concentrations, especially DPL, it loses its fluid permeability and can support a pressure of physiological saline of over 272 torr without bursting through. When the saline is replaced by isotonic ammonium chloride solution, the average penetration pressure is reduced to 187 torr. This is discussed in relation to the known production of ammonia upon hyperbaric exposure (1) and the competition of the resulting positive ammonium ions for the negative sites on the alveolar wall previously occupied by the positive quaternary ammonium ions of the effectively cationic lung surfactant. Successful replacement must then promote edema formation. This is put forward as a possible mechanism for the indirect (blood-borne) effect of oxygen upon the lung. It offers possible explanations for the potentiation of pulmonary oxygen poisoning by higher partial pressures or higher molecular weights of the inert gases present and the finding that increased permeability of epithelium precedes edema formation (18).
B A Hills
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Aviation, space, and environmental medicine     Volume:  53     ISSN:  0095-6562     ISO Abbreviation:  Aviat Space Environ Med     Publication Date:  1982 Jul 
Date Detail:
Created Date:  1982-10-12     Completed Date:  1982-10-12     Revised Date:  2006-04-17    
Medline Journal Info:
Nlm Unique ID:  7501714     Medline TA:  Aviat Space Environ Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  658-62     Citation Subset:  IM; S    
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MeSH Terms
Ammonium Chloride / toxicity*
Membranes, Artificial*
Methylcellulose* / analogs & derivatives
Models, Biological
Oxygen / toxicity
Pulmonary Edema / chemically induced
Pulmonary Surfactants / antagonists & inhibitors*
Reg. No./Substance:
0/Membranes, Artificial; 0/Pulmonary Surfactants; 12125-02-9/Ammonium Chloride; 7782-44-7/Oxygen; 9004-32-4/Carboxymethylcellulose; 9004-67-5/Methylcellulose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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