Document Detail

Pulmonary oxygen toxicity in the guinea pig. Effect of indomethacin.
MedLine Citation:
PMID:  2714157     Owner:  NLM     Status:  MEDLINE    
Deleterious pulmonary effects of hyperoxia are thought, in part, to be mediated by high-energy radicals and inflammatory reactions. It has been suggested that arachidonate metabolites, such as leukotrienes, may be responsible for the latter mechanism. We sought to demonstrate that concurrent exposure to hyperoxia and indomethacin, a potent inhibitor of cyclooxygenase, would increase pulmonary inflammation. A total of 50 female guinea pigs were treated as pairs with 95.6% oxygen or air and separately with 0.3 mg/kg of indomethacin or normal saline every 12 h for 3 days. A significant increase in leukocytes in bronchopulmonary lavage subsequent to combined oxygen and indomethacin treatment was observed when compared with either oxygen, indomethacin, or air treatments alone (p less than 0.05). Although oxygen treatment did alter pulmonary volume-pressure relations (p less than 0.05), hyperoxia alone or with concurrent indomethacin treatment did not alter elastance or histologic structures. These findings suggest that pulmonary inflammation in response to hyperoxia may be augmented by indomethacin. We speculate that increased lipoxygenase products of arachidonate metabolism may be partially responsible for these changes.
J D Roberts; W Oh
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Developmental pharmacology and therapeutics     Volume:  12     ISSN:  0379-8305     ISO Abbreviation:  Dev Pharmacol Ther     Publication Date:  1989  
Date Detail:
Created Date:  1989-06-09     Completed Date:  1989-06-09     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8003947     Medline TA:  Dev Pharmacol Ther     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  106-12     Citation Subset:  IM    
Department of Pediatrics, Women and Infants' Hospital, Providence, R.I.
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MeSH Terms
Bronchi / cytology
Guinea Pigs
Indomethacin / pharmacology*
Lung / cytology,  pathology,  physiopathology
Lung Diseases / chemically induced*,  physiopathology
Oxygen / toxicity*
Grant Support
T32 HD 07232-04/HD/NICHD NIH HHS
Reg. No./Substance:
53-86-1/Indomethacin; 7782-44-7/Oxygen

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