Document Detail


Pulmonary outcome differences in U.S. and French cystic fibrosis cohorts diagnosed through newborn screening.
MedLine Citation:
PMID:  19926349     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: A comparison of the longitudinal progression of lung disease in cystic fibrosis patients identified through newborn screening (NBS) in cohorts located in two different countries has never been performed and was the primary objective of this study.
METHODS: The study included 56 patients in Brittany diagnosed through NBS between 1989 and 1994 and 69 similar patients in Wisconsin between 1985 and 1994. The onset and progression of lung disease was radiographically quantified using the Wisconsin Chest X-ray (WCXR) scoring system. A single pediatric pulmonologist blinded to all identifiers scored the films.
RESULTS: Generalized estimating equation analyses adjusted for age, genotype, sex, pancreatic insufficiency, and meconium ileus showed worse WCXR scores in Brittany patients compared to Wisconsin patients (average score difference=4.48; p<0.001). Percent predicted FEV1 was also worse among Brittany patients (p<0.001).
CONCLUSIONS: The finding of milder radiographically-quantified lung disease using the WCXR scoring system, as well as better FEV1 values, may be explained by variations in nutrition, environmental exposures, or healthcare delivery.
Authors:
Aimee C Walsh; Gilles Rault; Zhanhai Li; Virginie Scotet; Ingrid Duguépéroux; Claude Férec; Michel Roussey; Anita Laxova; Philip M Farrell;
Related Documents :
8148449 - Chronic fatigue syndrome and a disorder resembling sjögren's syndrome: preliminary rep...
3932089 - Cystic fibrosis--a review of 26 adolescent and adult patients.
7543119 - Selective media for isolation of burkholderia (pseudomonas) cepacia from the respirator...
18923789 - Improvements in lung function of a pediatric cystic fibrosis population in a developing...
18248859 - Zinc therapy for night blindness in cystic fibrosis.
3600039 - Patient-spouse agreement on the drinking behaviors of alcoholics.
19324259 - Delayed-enhanced magnetic resonance imaging in nonischemic cardiomyopathy: utility for ...
17354139 - Liver embolization with trisacryl gelatin microspheres (embosphere) in patients with ne...
19774199 - Differentiation of convulsive syncope from epilepsy with an implantable loop recorder.
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2009-11-18
Journal Detail:
Title:  Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society     Volume:  9     ISSN:  1873-5010     ISO Abbreviation:  J. Cyst. Fibros.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-02-04     Completed Date:  2010-04-22     Revised Date:  2014-09-24    
Medline Journal Info:
Nlm Unique ID:  101128966     Medline TA:  J Cyst Fibros     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  44-50     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Bronchiectasis / epidemiology,  radiography
Child
Child, Preschool
Cohort Studies
Cystic Fibrosis / epidemiology*,  radiography*
Female
Forced Expiratory Volume
France / epidemiology
Humans
Infant
Infant, Newborn
Longitudinal Studies
Lung / radiography*
Male
Mass Chest X-Ray
Neonatal Screening*
Retrospective Studies
Risk Factors
United States / epidemiology
Wisconsin / epidemiology
Grant Support
ID/Acronym/Agency:
1UL1RR025011/RR/NCRR NIH HHS; DK 34108/DK/NIDDK NIH HHS; M01 RR003186/RR/NCRR NIH HHS; M01 RR003186-225571/RR/NCRR NIH HHS; M01 RR03186/RR/NCRR NIH HHS; R01 DK034108/DK/NIDDK NIH HHS; R01 DK034108-23/DK/NIDDK NIH HHS; UL1 RR025011/RR/NCRR NIH HHS; UL1 RR025011-025923/RR/NCRR NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Control of the G2/M checkpoints after exposure to low doses of ionising radiation: Implications for ...
Next Document:  Comparison of the sensitivity of evaporative universal detectors and LC/MS in the HILIC and the reve...