Document Detail


Pulmonary nocardiosis developed in a hematopoietic stem cell transplant recipient with bronchiolitis obliterans.
MedLine Citation:
PMID:  20647664     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
The chronic graft-versus-host disease often requires unceasing immunosuppressive therapy (IST), which increases a risk of infectious complications in hematopoietic stem cell transplantation (HSCT) recipients. We report an adult T-cell leukemia/lymphoma case who developed pulmonary nocardiosis, a rare pulmonary complication, after allogeneic HSCT despite administration of the prophylactic trimethoprim-sulfamethoxazole (TMP/STX). The inhaled corticosteroid in addition to systemic IST had been started for bronchiolitis obliterance 4 months prior to nocardiosis development. The patient was successfully treated with an increased dose of TMP/STX combined with meropenem. Transplantation physicians should keep this rare pulmonary complication in mind during sustained IST.
Authors:
Ruriko Nishida; Yasuo Mori; Hiromi Iwasaki; Takahito Tokuyama; Kenjiro Kamezaki; Yoji Nagasaki; Hideyo Oka; Kohta Miyawaki; Noriyuki Saito; Katsuto Takenaka; Naoki Harada; Toshihiro Miyamoto; Takanori Teshima; Koichi Akashi
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2010-07-15
Journal Detail:
Title:  Internal medicine (Tokyo, Japan)     Volume:  49     ISSN:  1349-7235     ISO Abbreviation:  Intern. Med.     Publication Date:  2010  
Date Detail:
Created Date:  2010-07-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9204241     Medline TA:  Intern Med     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1441-4     Citation Subset:  IM    
Affiliation:
Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.
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