Document Detail


Pulmonary necrotizing sarcoid granulomatosis in a patient with primary biliary cirrhosis
MedLine Citation:
PMID:  20812157     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
HISTORY AND ADMISSION FINDINGS: A 53-year-old woman presented with recurrent episodes of cough and non-specific pulmonary symptoms. For many years she had been known to have primary biliary cirrhosis. INVESTIGATIONS: The chest X-ray showed multiple pulmonary nodules. Microbiological examination did not detect any pathogen and transbronchial biopsy of the pulmonary nodules failed to provide a diagnosis. Histology of a surgical lung biopsy showed interstitial inflammation, vasculitis and non-caseating granulomas. TREATMENT AND COURSE: The findings indicated necrotizing sarcoid granulomatosis. During oral corticoid therapy the pulmonary nodules regressed within a few weeks. The patient has remained free of pulmonary symptoms. CONCLUSION: Pulmonary necrotizing sarcoid granulomatosis is a rare condition to consider in the differential diagnosis of pulmonary nodules. Because of the histological findings and its benign course it resembles sarcoidosis.
Authors:
D Frechen; C Cornelissen; K Schreiner; J Jäkel; S Krüger
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Publication Detail:
Type:  Case Reports; English Abstract; Journal Article     Date:  2010-09-01
Journal Detail:
Title:  Deutsche medizinische Wochenschrift (1946)     Volume:  135     ISSN:  1439-4413     ISO Abbreviation:  Dtsch. Med. Wochenschr.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-02     Completed Date:  2010-09-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0006723     Medline TA:  Dtsch Med Wochenschr     Country:  Germany    
Other Details:
Languages:  ger     Pagination:  1733-6     Citation Subset:  IM    
Copyright Information:
Copyright Georg Thieme Verlag KG Stuttgart . New York.
Affiliation:
Medizinische Klinik I, Universitätsklinikum der RWTH Aachen, Aachen. dfrechen@ukaachen.de
Vernacular Title:
Nekrotisierende sarkoidale Granulomatose der Lunge bei einer Patientin mit primärer biliärer Leberzirrhose.
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MeSH Terms
Descriptor/Qualifier:
Biopsy
Cough
Diagnosis, Differential
Female
Glucocorticoids / therapeutic use
Granuloma, Respiratory Tract / complications,  diagnosis*,  drug therapy
Humans
Liver Cirrhosis, Biliary / complications*
Lung / pathology*
Middle Aged
Necrosis / complications,  diagnosis
Prednisolone / therapeutic use
Sarcoidosis, Pulmonary / complications,  diagnosis*,  drug therapy
Tomography, X-Ray Computed
Chemical
Reg. No./Substance:
0/Glucocorticoids; 50-24-8/Prednisolone

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