| Pulmonary necrotizing sarcoid granulomatosis in a patient with primary biliary cirrhosis | |
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MedLine Citation:
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PMID: 20812157 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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HISTORY AND ADMISSION FINDINGS: A 53-year-old woman presented with recurrent episodes of cough and non-specific pulmonary symptoms. For many years she had been known to have primary biliary cirrhosis. INVESTIGATIONS: The chest X-ray showed multiple pulmonary nodules. Microbiological examination did not detect any pathogen and transbronchial biopsy of the pulmonary nodules failed to provide a diagnosis. Histology of a surgical lung biopsy showed interstitial inflammation, vasculitis and non-caseating granulomas. TREATMENT AND COURSE: The findings indicated necrotizing sarcoid granulomatosis. During oral corticoid therapy the pulmonary nodules regressed within a few weeks. The patient has remained free of pulmonary symptoms. CONCLUSION: Pulmonary necrotizing sarcoid granulomatosis is a rare condition to consider in the differential diagnosis of pulmonary nodules. Because of the histological findings and its benign course it resembles sarcoidosis. |
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Authors:
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D Frechen; C Cornelissen; K Schreiner; J Jäkel; S Krüger |
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Publication Detail:
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Type: Case Reports; English Abstract; Journal Article Date: 2010-09-01 |
Journal Detail:
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Title: Deutsche medizinische Wochenschrift (1946) Volume: 135 ISSN: 1439-4413 ISO Abbreviation: Dtsch. Med. Wochenschr. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-02 Completed Date: 2010-09-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0006723 Medline TA: Dtsch Med Wochenschr Country: Germany |
Other Details:
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Languages: ger Pagination: 1733-6 Citation Subset: IM |
Copyright Information:
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Copyright Georg Thieme Verlag KG Stuttgart . New York. |
Affiliation:
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Medizinische Klinik I, Universitätsklinikum der RWTH Aachen, Aachen. dfrechen@ukaachen.de |
Vernacular Title:
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Nekrotisierende sarkoidale Granulomatose der Lunge bei einer Patientin mit primärer biliärer Leberzirrhose. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Biopsy Cough Diagnosis, Differential Female Glucocorticoids / therapeutic use Granuloma, Respiratory Tract / complications, diagnosis*, drug therapy Humans Liver Cirrhosis, Biliary / complications* Lung / pathology* Middle Aged Necrosis / complications, diagnosis Prednisolone / therapeutic use Sarcoidosis, Pulmonary / complications, diagnosis*, drug therapy Tomography, X-Ray Computed |
| Chemical | |
Reg. No./Substance:
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0/Glucocorticoids; 50-24-8/Prednisolone |
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