| Pulmonary mucosal dendritic cells in T-cell activation: implications for TB therapy. | |
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MedLine Citation:
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PMID: 21348588 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Mycobacterium tuberculosis, the causative agent of pulmonary TB, causes chronic intracellular infection of lung-resident antigen-presenting cells, including macrophages and dendritic cells (DCs). Life-long bacterial control requires robust T-cell immune responses. Lung DCs are critical for initiating and co-ordinating adaptive immune responses against TB. The recent description of previously uncharacterized DC subsets has prompted the re-examination of lung DCs and their role in priming antimycobacterial T-cell responses. While there is some data on these new DCs in their naive state, very little is known about how these DCs respond to pulmonary mycobacterial infection. In this article, we attempt to identify the major antigen-presenting cell subsets that may be critical to lymph node homing, T-cell priming and controlling mycobacterial infection. We further examine the areas of DC heterogeneity that may relate to differential susceptibility between mouse strains. Furthermore, we discuss how DCs may be manipulated and exploited as a cell-based prophylactic TB vaccine and the prospect of using this strategy for post-M. tuberculosis exposure settings. |
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Authors:
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Sarah McCormick; Christopher R Shaler; Zhou Xing |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Expert review of respiratory medicine Volume: 5 ISSN: 1747-6356 ISO Abbreviation: Expert Rev Respir Med Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-02-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101278196 Medline TA: Expert Rev Respir Med Country: England |
Other Details:
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Languages: eng Pagination: 75-85 Citation Subset: IM |
Affiliation:
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Centre for Gene Therapeutics, M.G. DeGroote Institute for Infectious Disease Research, and Department of Pathology & Molecular Medicine, McMaster University, Hamilton, ON, Canada; MDCL-4012, McMaster University, Hamilton, ON L8N 3Z5, Canada. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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