Document Detail

Pulmonary morphofunctional effects of acute myocardial infarction.
MedLine Citation:
PMID:  10573216     Owner:  NLM     Status:  MEDLINE    
Acute myocardial infarction (AMI) may yield several respiratory changes. Nevertheless, no comprehensive pulmonary morphological/physiological correlation has been performed under this condition. The aims of the present investigation were: 1) to determine the respiratory parameters in an experimental model of coronary artery occlusion, 2) to relate these results to findings from lung histopathology, and 3) to evaluate the effects of propranolol used prior to AMI. Twenty-eight rats were anaesthetized and mechanically ventilated. In the control group (C), a suture line was passed around the left anterior descending coronary artery (LADCA). The infarct group (I) was similarly prepared but the LADCA was ligated and infarct resulted. In the control/propranolol (CP) and infarct/propranolol (IP) groups, propranolol was intravenously injected 5 min before surgery as performed in groups C and I, respectively. Lung static (EL,st) and dynamic (EL,dyn) elastances, airway resistance (RL,int), and viscoelastic/inhomogeneous pressure (deltaP2L) were determined before and 30, 60 and 120 min after surgery. In group I, EL,st, EL,dyn, RL,int and deltaP2L increased progressively throughout the experiment, and were higher than those found in groups C, CP and IP. All respiratory parameters but EL,st remained unaltered in group IP. Lung histopathological examination demonstrated alveolar, interstitial and intrabronchial oedema in group I. Group IP showed only interstitial oedema. Acute myocardial infarction yields lung resistive, elastic and viscoelastic changes. The last two results from alveolar and interstitial oedema, respectively. The previous use of propranolol diminishes respiratory changes.
D S Faffe; P S Chagas; A S Medeiros; E A Saad; P H Saldiva; P R Rocco; W A Zin
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The European respiratory journal     Volume:  14     ISSN:  0903-1936     ISO Abbreviation:  Eur. Respir. J.     Publication Date:  1999 Oct 
Date Detail:
Created Date:  1999-12-07     Completed Date:  1999-12-07     Revised Date:  2013-05-23    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  751-8     Citation Subset:  IM    
Laboratory of Respiration Physiology, Carlos Chagas Filho Biophysics Institute and Thoracic Disease Institute, Federal University of Rio de Janeiro, RJ, Brazil.
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MeSH Terms
Adrenergic beta-Antagonists / therapeutic use
Blood Gas Analysis
Disease Models, Animal
Lung / pathology,  physiopathology*
Myocardial Infarction / complications*,  drug therapy
Propranolol / therapeutic use
Pulmonary Edema / etiology,  pathology,  physiopathology*
Rats, Wistar
Respiratory Mechanics*
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 525-66-6/Propranolol

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