Document Detail

Pulmonary mechanics in normal rats.
MedLine Citation:
PMID:  606698     Owner:  NLM     Status:  MEDLINE    
A versatile, whole-body pressure, or volume plethysmographic system for the study of pulmonary mechanics in anesthetized, tracheotomized rats has been described. Lung volumes and lung compliance values were in good agreement with those previously reported. Pulmonary resistance and chest wall compliance values were lower than those previously reported. Total dynamic compliance remained independent of respiratory frequency between 40 and 320 breaths/min. Flow-limiting behavior was demonstrated from a series of imposed forced expiratory maneuvers of graded effort. With a deflation pressure of 30 cmH2O, the effort-independent range of maximum flow extended to 40-50% of vital capacity. Maximal flow-static recoil pressure relationships were essentially linear over the effort independent portion of the flow-volume curve. Substitution of a low-density gas mixture (80% He-20% O2) for air resulted in increased forced expiratory flow rates but the magnitude of the response was considerably less than that which has been reported in man.
L Diamond; M O'Donnell
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of applied physiology: respiratory, environmental and exercise physiology     Volume:  43     ISSN:  0161-7567     ISO Abbreviation:  J Appl Physiol Respir Environ Exerc Physiol     Publication Date:  1977 Dec 
Date Detail:
Created Date:  1978-04-26     Completed Date:  1978-04-26     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  7801242     Medline TA:  J Appl Physiol Respir Environ Exerc Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  942-8     Citation Subset:  IM    
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MeSH Terms
Airway Resistance
Atmospheric Pressure
Lung / physiology*
Lung Compliance
Maximal Expiratory Flow-Volume Curves
Rats / physiology*
Respiratory Function Tests / methods

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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