| Pulmonary mechanics during isoflurane, sevoflurane and desflurane anaesthesia. | |
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MedLine Citation:
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PMID: 12859465 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study was designed to investigate the effects of desflurane on bronchial smooth muscle tone, following intubation and to compare these effects with isoflurane and sevoflurane. Patients were randomly divided into three groups to receive, isoflurane (n = 22), sevoflurane (n = 23), or desflurane (n = 22). Peak inspiratory pressure (PIP), respiratory resistance (Rr) and dynamic compliance (Cdyn) measurements were recorded at three time points; After the beginning of ventilation and before inhalation agent was started, following 5 min of ventilation with 1 MAC (minimum alveolar concentration) inhalation agent and following 5 min of 2 MAC inhalation agent. We found that all inhalation agents caused a significant decrease in Peak Inspiratory Pressure (PIP) and respiratory resistance (Rr), and an increase in dynamic compliance (Cdyn) at 1 MAC concentrations. When the agent concentration was increased to 2 MAC, desflurane caused a significant increase in Rr and PIP and a decrease in Cdyn. We concluded that desflurane, like isoflurane and sevoflurane, exhibits a bronchodilator effect at 1 MAC concentration. However, increasing the concentration to 2 MAC caused an increase in airway resistance with desflurane, whilst sevoflurane and isoflurane continued to have a bronchodilator effect. |
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Authors:
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Y Dikmen; E Eminoglu; Z Salihoglu; S Demiroluk |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Anaesthesia Volume: 58 ISSN: 0003-2409 ISO Abbreviation: Anaesthesia Publication Date: 2003 Aug |
Date Detail:
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Created Date: 2003-07-15 Completed Date: 2003-09-11 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370524 Medline TA: Anaesthesia Country: England |
Other Details:
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Languages: eng Pagination: 745-8 Citation Subset: AIM; IM |
Affiliation:
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University of Istanbul, Medical School of Cerrahpasa, Anaesthesia, Cerrahpasa 34301, Istanbul, Turkey. ydikmen@istanbul.edu.tr |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Airway Resistance / drug effects Analysis of Variance Anesthetics, Inhalation / pharmacology* Dose-Response Relationship, Drug Female Humans Isoflurane / analogs & derivatives*, pharmacology* Lung Compliance / drug effects Male Methyl Ethers / pharmacology Middle Aged Respiratory Mechanics / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Inhalation; 0/Methyl Ethers; 26675-46-7/Isoflurane; 28523-86-6/sevoflurane; 57041-67-5/desflurane |
| Comments/Corrections | |
Comment In:
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Anaesthesia. 2003 Dec;58(12):1248; author reply 1249
[PMID:
14705712
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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