Document Detail

Pulmonary mechanics during isoflurane, sevoflurane and desflurane anaesthesia.
MedLine Citation:
PMID:  12859465     Owner:  NLM     Status:  MEDLINE    
This study was designed to investigate the effects of desflurane on bronchial smooth muscle tone, following intubation and to compare these effects with isoflurane and sevoflurane. Patients were randomly divided into three groups to receive, isoflurane (n = 22), sevoflurane (n = 23), or desflurane (n = 22). Peak inspiratory pressure (PIP), respiratory resistance (Rr) and dynamic compliance (Cdyn) measurements were recorded at three time points; After the beginning of ventilation and before inhalation agent was started, following 5 min of ventilation with 1 MAC (minimum alveolar concentration) inhalation agent and following 5 min of 2 MAC inhalation agent. We found that all inhalation agents caused a significant decrease in Peak Inspiratory Pressure (PIP) and respiratory resistance (Rr), and an increase in dynamic compliance (Cdyn) at 1 MAC concentrations. When the agent concentration was increased to 2 MAC, desflurane caused a significant increase in Rr and PIP and a decrease in Cdyn. We concluded that desflurane, like isoflurane and sevoflurane, exhibits a bronchodilator effect at 1 MAC concentration. However, increasing the concentration to 2 MAC caused an increase in airway resistance with desflurane, whilst sevoflurane and isoflurane continued to have a bronchodilator effect.
Y Dikmen; E Eminoglu; Z Salihoglu; S Demiroluk
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Anaesthesia     Volume:  58     ISSN:  0003-2409     ISO Abbreviation:  Anaesthesia     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-07-15     Completed Date:  2003-09-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370524     Medline TA:  Anaesthesia     Country:  England    
Other Details:
Languages:  eng     Pagination:  745-8     Citation Subset:  AIM; IM    
University of Istanbul, Medical School of Cerrahpasa, Anaesthesia, Cerrahpasa 34301, Istanbul, Turkey.
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MeSH Terms
Airway Resistance / drug effects
Analysis of Variance
Anesthetics, Inhalation / pharmacology*
Dose-Response Relationship, Drug
Isoflurane / analogs & derivatives*,  pharmacology*
Lung Compliance / drug effects
Methyl Ethers / pharmacology
Middle Aged
Respiratory Mechanics / drug effects*
Reg. No./Substance:
0/Anesthetics, Inhalation; 0/Methyl Ethers; 26675-46-7/Isoflurane; 28523-86-6/sevoflurane; 57041-67-5/desflurane
Comment In:
Anaesthesia. 2003 Dec;58(12):1248; author reply 1249   [PMID:  14705712 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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