Document Detail

Pulmonary manifestations in patients with malignant melanoma during BCG immunotherapy. A preliminary report.
MedLine Citation:
PMID:  436519     Owner:  NLM     Status:  MEDLINE    
Ten patients with malignant melanoma who were treated with bacillus Calmette-Guérin (BCG) were studied with chest roentgenograms, scintiscans with radioactive 67gallium citrate, and the single-breath diffusing capacity of carbon monoxide (Dsb). Three patients (stage 1B) with normal findings had no evidence of progression of disease. Seven patients had abnormal findings on at least one test. Two patients (stage 3B and stage 4B) with focal uptake in the lungs on the scintiscan had metastatic melanoma. Three patients (stage 3B) with diffuse uptake on the scintiscan and a reduced Dsb had no evidence of progression of disease. One patient (stage 1B) with an abnormal chest roentgenogram had a benign pleural effusion, and one patient (stage 4B) with a reduced Dsb was free of melanoma. A diffuse increase in the uptake of radioactive 67gallium in the lungs and a low Dsb may not indicate progression of melanoma. On the other hand, a focal uptake of 67gallium in the lungs is highly suggestive of metastatic disease.
C Bilgi; N E Brown; T A McPherson; B Lentle
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chest     Volume:  75     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  1979 Jun 
Date Detail:
Created Date:  1979-07-28     Completed Date:  1979-07-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  685-7     Citation Subset:  AIM; IM    
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MeSH Terms
Administration, Oral
BCG Vaccine / administration & dosage,  adverse effects,  therapeutic use*
Gallium Radioisotopes / diagnostic use
Injections, Intradermal
Lung Neoplasms / diagnosis*,  radionuclide imaging
Lymphatic Metastasis
Melanoma / immunology,  therapy*
Middle Aged
Neoplasm Metastasis
Pleural Effusion / etiology
Pulmonary Diffusing Capacity
Skin Neoplasms / immunology,  therapy*
Reg. No./Substance:
0/BCG Vaccine; 0/Gallium Radioisotopes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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