Document Detail

Pulmonary macrophage phagocytosis and enzyme production after in vivo exposure to silica dust.
MedLine Citation:
PMID:  6302949     Owner:  NLM     Status:  MEDLINE    
Guinea pigs were exposed to silica dust (SiO2) aerosols at 6, 13, 28, and 46 mg/m3 for 3 weeks and examined 4, 8, 16, and 23 weeks later. Twenty-four milligrams of TiO2 per cubic meter served as the control dust. Lung weights were increased at 8 weeks and later. Free lung cells showed a tendency to decrease in phagocytosis capacity at 8 weeks after cessation of exposure and later. Alveolar macrophage production of N-acetyl-beta-D-glucosaminidase, cathepsin D, and acid phosphatase was decreased at 8 weeks after exposure and later. The relationship between the depressant effect on macrophages and the absence of an exposure-related polymorphonuclear neutrophil response for the development of fibrosis could be part of the mechanism behind fibrosis.
B Fogelmark; M Sjöstrand; R Bergström; R Rylander
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Toxicology and applied pharmacology     Volume:  68     ISSN:  0041-008X     ISO Abbreviation:  Toxicol. Appl. Pharmacol.     Publication Date:  1983 Mar 
Date Detail:
Created Date:  1983-06-10     Completed Date:  1983-06-10     Revised Date:  2006-04-19    
Medline Journal Info:
Nlm Unique ID:  0416575     Medline TA:  Toxicol Appl Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  152-9     Citation Subset:  IM    
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MeSH Terms
Dust / adverse effects*
Guinea Pigs
Lung / drug effects*
Macrophages / drug effects*,  enzymology
Neutrophils / drug effects
Phagocytosis / drug effects*
Silicon Dioxide / toxicity*
Reg. No./Substance:
0/Dust; 7631-86-9/Silicon Dioxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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