Document Detail

Pulmonary involvement in systemic sclerosis. Association with anti-Scl 70 antibody and digital pitting.
MedLine Citation:
PMID:  3622029     Owner:  NLM     Status:  MEDLINE    
The association of clinical and serologic features of 34 patients with systemic sclerosis was examined. Anti-Scl 70 antibody was found to identify patients with abnormal pulmonary function, particularly impaired diffusion (p less than 0.005), as well as patients with digital pitting scars (p less than 0.025). In addition, the presence of digital pitting scars correlated with impaired diffusion (p less than 0.005), suggesting that interstitial pulmonary disease in systemic sclerosis may, like digital pitting, be secondary to vascular pathology. Anticentromere antibody-positive patients were less likely to have abnormalities of pulmonary function (p less than 0.001).
M N Manoussakis; S H Constantopoulos; A E Gharavi; H M Moutsopoulos
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Chest     Volume:  92     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  1987 Sep 
Date Detail:
Created Date:  1987-10-13     Completed Date:  1987-10-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  509-13     Citation Subset:  AIM; IM    
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MeSH Terms
Autoantibodies / immunology*
Autoimmune Diseases / immunology*
Centromere / immunology
Nuclear Proteins*
Nucleoproteins / immunology*
Pulmonary Diffusing Capacity
Pulmonary Fibrosis / etiology*,  immunology
Scleroderma, Systemic / complications*,  immunology
Reg. No./Substance:
0/Autoantibodies; 0/Nuclear Proteins; 0/Nucleoproteins; 0/Scl 70 antigen, human

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