Document Detail


Pulmonary involvement in polymyositis and in dermatomyositis.
MedLine Citation:
PMID:  9676766     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To assess prevalence, characteristics, and predictive factors of pulmonary involvement in polymyositis (PM) and dermatomyositis (DM). METHODS: The medical records of 55 consecutive patients with PM and DM between 1983 and 1996 were reviewed. The criteria for diagnosis of PM and DM were based upon Bohan and Peter criteria. RESULTS: Twenty-two patients (40%) developed lung impairment with a mean of 17 months after onset of PM and DM. The 3 main types of pulmonary disorders were interstitial lung disease (41%), ventilatory insufficiency with bronchopneumonia (22.8%), and alveolitis (with pulmonary function tests revealing restrictive pattern, low diffusing capacity, and normal computerized tomography) (36.2%). Both morbidity and mortality rates were as high as 40 and 27%, respectively, in PM and DM patients with lung involvement. Moreover, for the group with pulmonary diseases, serum GOT and ferritin levels were higher (p = 0.01 and p = 0.02) and the presence of anti-Jo-1 antibody and characteristic microangiopathy were more frequent (p < 0.05 and p = 0.0002). CONCLUSION: This series reveals both high prevalence (40%) and severity of pulmonary involvement in PM and DM. Our findings also suggest that high serum GOT and ferritin levels, presence of anti-Jo-1 antibody and characteristic microangiopathy may have predictive value and should encourage the search for pulmonary dysfunction and interstitial lung disease in patients with PM and DM.
Authors:
I Marie; P Y Hatron; E Hachulla; B Wallaert; U Michon-Pasturel; B Devulder
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of rheumatology     Volume:  25     ISSN:  0315-162X     ISO Abbreviation:  J. Rheumatol.     Publication Date:  1998 Jul 
Date Detail:
Created Date:  1998-09-29     Completed Date:  1998-09-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7501984     Medline TA:  J Rheumatol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  1336-43     Citation Subset:  IM    
Affiliation:
Département de Médecine Interne, Hôpital Claude Huriez, CHU Lille, France.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Biological Markers / blood
Child
Child, Preschool
Dermatomyositis / blood,  complications,  diagnosis,  epidemiology*
Female
Humans
Lung Diseases / blood,  complications,  diagnosis,  epidemiology*
Male
Middle Aged
Polymyositis / blood,  complications,  diagnosis,  epidemiology*
Prognosis
Retrospective Studies
Chemical
Reg. No./Substance:
0/Biological Markers
Comments/Corrections
Comment In:
J Rheumatol. 1999 Aug;26(8):1852-4   [PMID:  10451094 ]

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