Document Detail


Pulmonary involvement in inflammatory bowel disease.
MedLine Citation:
PMID:  20954282     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: To determine the relationship of pulmonary abnormalities and bowel disease activity in inflammatory bowel disease (IBD).
METHODS: Thirty ulcerative colitis (UC) and nine Crohn's disease patients, and 20 control subjects were enrolled in this prospective study. Detailed clinical information was obtained. Extent and activity of the bowel disease were established endoscopically. Each patient underwent pulmonary function tests and high-resolution computed tomography (HRCT). Blood samples for measurement of C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), angiotensin converting enzyme and total IgE were delivered by the patients.
RESULTS: Ten (25.6%) patients had respiratory symptoms. A pulmonary function abnormality was present in 22 of 39 patients. Among all patients, the most prevalent abnormalities in lung functions were a decrease in forced expiratory volume in 1 s (FEV1), FEV1/forced vital capacity (FVC), forced expiratory flow (FEF) 25%-75%, transfer coefficient for carbon monoxide (DLCO), DLCO/alveolar volume. Increased respiratory symptoms score was associated with high endoscopic activity index in UC patients. Endoscopic and clinical activities in UC patients were correlated with FEV1, FEV1/FVC, and FEF 25%-75%. Smoking status, duration of disease and medication were not correlated with pulmonary physiological test results, HRCT abnormalities, clinical/endoscopic disease activity, CRP, ESR or total IgE level or body mass index.
CONCLUSION: It is important that respiratory manifestations are recognized and treated early in IBD. Otherwise, they can lead to destructive and irreversible changes in the airway wall.
Authors:
Aydin Yilmaz; Nilgün Yilmaz Demirci; Derya Hoşgün; Enver Uner; Yurdanur Erdoğan; Atila Gökçek; Atalay Cağlar
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  World journal of gastroenterology : WJG     Volume:  16     ISSN:  2219-2840     ISO Abbreviation:  World J. Gastroenterol.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-18     Completed Date:  2011-02-01     Revised Date:  2014-05-20    
Medline Journal Info:
Nlm Unique ID:  100883448     Medline TA:  World J Gastroenterol     Country:  China    
Other Details:
Languages:  eng     Pagination:  4952-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Biological Markers / blood
Blood Sedimentation
Bronchial Provocation Tests
C-Reactive Protein / analysis
Case-Control Studies
Colitis, Ulcerative / complications*,  diagnosis
Crohn Disease / complications*,  diagnosis
Endoscopy, Gastrointestinal
Female
Forced Expiratory Volume
Humans
Immunoglobulin E / blood
Lung / physiopathology*,  radiography
Lung Diseases / diagnosis,  etiology*,  physiopathology
Male
Maximal Midexpiratory Flow Rate
Middle Aged
Peptidyl-Dipeptidase A / blood
Predictive Value of Tests
Prospective Studies
Pulmonary Diffusing Capacity
Singapore
Tomography, X-Ray Computed
Vital Capacity
Chemical
Reg. No./Substance:
0/Biological Markers; 37341-29-0/Immunoglobulin E; 9007-41-4/C-Reactive Protein; EC 3.4.15.1/Peptidyl-Dipeptidase A
Comments/Corrections

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