Document Detail

Pulmonary intra-alveolar siderophages in SIDS and suffocation: a San Diego SIDS/SUDC Research Project report.
MedLine Citation:
PMID:  16813458     Owner:  NLM     Status:  MEDLINE    
Pulmonary intra-alveolar siderophages (PS) have been suggested as a marker of previous attempts at imposed suffocation in infants dying suddenly and unexpectedly. The aims of this study were to (1) compare PS counts between cases of sudden infant death syndrome (SIDS) and a control group comprised of infants whose deaths were attributed to accidental or inflicted suffocation, (2) compare clinical variables in SIDS and control suffocation cases, and (3) review individual cases irrespective of the cause and manner of death with an average PS count greater than 200 per 20 high-power fields (hpf) per lung lobe. Retrospective assessment of siderophages in available iron-stained lung sections was undertaken in 91 SIDS cases and 29 cases of death due to suffocation (27 accidents and 2 homicides) from the San Diego SIDS and Sudden Unexplained Death in Childhood (SUDC) Research Project (SDSSRP) database. Neither the means of the log-transformed PS counts nor the medians of the raw PS counts were significantly different between the SIDS and control suffocation groups. The distributions of the PS data were different, however-the range was wider in the SIDS group. Only 6% of each group had a history of prior apparent life-threatening events. Approximately three fourths of the families from both groups had no prior referral to Child Protective Services. The number of PS varies widely in cases of sudden infant death caused by SIDS and accidental or inflicted suffocation and cannot be used as an independent variable to ascertain past attempts at suffocation.
Henry F Krous; Christopher Wixom; Amy E Chadwick; Elisabeth A Haas; Patricia D Silva; Christina Stanley
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-06-16
Journal Detail:
Title:  Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society     Volume:  9     ISSN:  1093-5266     ISO Abbreviation:  Pediatr. Dev. Pathol.     Publication Date:    2006 Mar-Apr
Date Detail:
Created Date:  2006-07-03     Completed Date:  2006-08-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9809673     Medline TA:  Pediatr Dev Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  103-14     Citation Subset:  IM    
Department of Pathology, Children's Hospital and Health Center, 3020 Children's Way, MC5007, San Diego, CA 92123, USA.
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MeSH Terms
Asphyxia / etiology,  pathology*
Biological Markers / metabolism
Gestational Age
Hemosiderin / metabolism*
Infant, Newborn
Infant, Premature
Macrophages, Alveolar / metabolism,  pathology*
Pulmonary Alveoli / metabolism,  pathology
Retrospective Studies
Siderosis / complications,  metabolism,  pathology*
Sudden Infant Death / etiology,  pathology*
Term Birth
Reg. No./Substance:
0/Biological Markers; 9011-92-1/Hemosiderin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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