Document Detail

Pulmonary interstitial pressure in premature rabbits.
MedLine Citation:
PMID:  8904015     Owner:  NLM     Status:  MEDLINE    
By micropuncture technique we measured pulmonary interstitial pressure (Pip) from birth up to 6 h postnatal age in anesthetized and paralyzed cesarian delivered term (31 days gestation) and premature (27 to 30 days gestation) rabbits. In term cesarian delivered rabbits Pip followed the time course of vaginally delivered rabbits, namely, it increased from about zero at birth up to about 5 cmH2O at 2 h, as a result of alveolar fluid reabsorption, subsequently it decreased becoming subatmospheric due to progressive interstitial fluid drainage. In ventilated lung regions of premature rabbits, Pip also peaked to about 5 cmH2O at 2 h but its subsequent decrease was markedly slowed down while in atelectatic regions of premature rabbits Pip remained slightly subatmospheric. Up to 6 h, the wet/dry weight ratio of the lung was higher in premature relative to vaginally and cesarian delivered term rabbits (at birth 8.4 +/- 0.9 vs. 7.5 +/- 0.8). In 29-31 days rabbits, plasma protein concentration at birth was 3.6 +/- 0.5 g/dl (within 95% confidence limits for vaginally delivered rabbits, considered as control) while in 27-28 days rabbit it was 3.1 +/- 0.4 g/dl (at the lower edge of control confidence limits). In the first postnatal hours, the increase in Pip favoured fluid reabsorption into pulmonary microcirculation in term cesarian delivered rabbits and in ventilated regions of premature rabbits. Conversely, in the atelectatic regions of premature rabbits the unchanged Pip value in the postnatal hours favours fluid filtration from microcirculation into lung interstitium.
G Miserocchi; B H Poskurica; M del Fabbro; B Crisafulli
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Respiration physiology     Volume:  102     ISSN:  0034-5687     ISO Abbreviation:  Respir Physiol     Publication Date:  1995 Dec 
Date Detail:
Created Date:  1997-03-14     Completed Date:  1997-03-14     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0047142     Medline TA:  Respir Physiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  239-49     Citation Subset:  IM    
Istituto de Fisiologia Umana, Universita degle Studi, Milan, Italy.
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MeSH Terms
Age Factors
Animals, Newborn / metabolism*
Blood Proteins / metabolism
Body Weight
Extracellular Space / chemistry
Gestational Age
Infant, Newborn
Lung / physiology*
Obstetric Labor, Premature
Organ Size
Pulmonary Circulation / physiology
Punctures / methods
Respiratory Mechanics
Surface-Active Agents / metabolism
Reg. No./Substance:
0/Blood Proteins; 0/Surface-Active Agents

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