| Pulmonary interstitial emphysema in the premature baboon with hyaline membrane disease. | |
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MedLine Citation:
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PMID: 6373147 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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During experiments designed to develop an appropriate ventilatory strategy for high-frequency ventilation (HFV) in the premature baboon with hyaline membrane disease (HMD), we observed the development of pulmonary interstitial emphysema (PIE). Four study groups of 5 animals each received positive-pressure ventilation and positive end-expiratory pressure (PPV/PEEP) or HFV and 1 of 3 sighing techniques. Pathologically, all animals ventilated with PPV/PEEP or HFV with a carefully controlled intermittent sigh developed dilatation of the distal conducting airway and alveolar duct, with poorly expanded pulmonary saccules. The imposition of a sigh with inappropriate timing or excessive volume ruptured the dilated airway walls and caused interstitial air to accumulate. This was evident from the location of striking dilation of the distal airways and pseudocysts in areas of atelectasis. Thus, early in the course of HMD when saccular aeration is minimal, the pathogenesis of PIE is related to airway rather than alveolar rupture. |
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Authors:
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N B Ackerman; J J Coalson; T J Kuehl; R Stoddard; L Minnick; M B Escobedo; D M Null; J L Robotham; R deLemos |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Critical care medicine Volume: 12 ISSN: 0090-3493 ISO Abbreviation: Crit. Care Med. Publication Date: 1984 Jun |
Date Detail:
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Created Date: 1984-07-13 Completed Date: 1984-07-13 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0355501 Medline TA: Crit Care Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 512-6 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Evaluation Studies as Topic Humans Hyaline Membrane Disease / therapy* Infant, Newborn Lung / pathology Papio Positive-Pressure Respiration Pulmonary Emphysema / etiology* Random Allocation Respiration, Artificial / adverse effects*, methods |
| Grant Support | |
ID/Acronym/Agency:
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HL 29354/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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