Document Detail

Pulmonary interstitial emphysema in the premature baboon with hyaline membrane disease.
MedLine Citation:
PMID:  6373147     Owner:  NLM     Status:  MEDLINE    
During experiments designed to develop an appropriate ventilatory strategy for high-frequency ventilation (HFV) in the premature baboon with hyaline membrane disease (HMD), we observed the development of pulmonary interstitial emphysema (PIE). Four study groups of 5 animals each received positive-pressure ventilation and positive end-expiratory pressure (PPV/PEEP) or HFV and 1 of 3 sighing techniques. Pathologically, all animals ventilated with PPV/PEEP or HFV with a carefully controlled intermittent sigh developed dilatation of the distal conducting airway and alveolar duct, with poorly expanded pulmonary saccules. The imposition of a sigh with inappropriate timing or excessive volume ruptured the dilated airway walls and caused interstitial air to accumulate. This was evident from the location of striking dilation of the distal airways and pseudocysts in areas of atelectasis. Thus, early in the course of HMD when saccular aeration is minimal, the pathogenesis of PIE is related to airway rather than alveolar rupture.
N B Ackerman; J J Coalson; T J Kuehl; R Stoddard; L Minnick; M B Escobedo; D M Null; J L Robotham; R deLemos
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Critical care medicine     Volume:  12     ISSN:  0090-3493     ISO Abbreviation:  Crit. Care Med.     Publication Date:  1984 Jun 
Date Detail:
Created Date:  1984-07-13     Completed Date:  1984-07-13     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0355501     Medline TA:  Crit Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  512-6     Citation Subset:  AIM; IM    
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MeSH Terms
Evaluation Studies as Topic
Hyaline Membrane Disease / therapy*
Infant, Newborn
Lung / pathology
Positive-Pressure Respiration
Pulmonary Emphysema / etiology*
Random Allocation
Respiration, Artificial / adverse effects*,  methods
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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