Document Detail

Pulmonary innate lymphoid cells are major producers of IL-5 and IL-13 in murine models of allergic asthma.
MedLine Citation:
PMID:  22539286     Owner:  NLM     Status:  MEDLINE    
Allergic asthma is characterized by chronic airway inflammation and hyperreactivity and is thought to be mediated by an adaptive T helper-2 (Th2) cell-type immune response. Here, we demonstrate that type 2 pulmonary innate lymphoid cells (ILC2s) significantly contribute to production of the key cytokines IL-5 and IL-13 in experimental asthma. In naive mice, lineage-marker negative ILC2s expressing IL-7Rα, CD25, Sca-1, and T1/ST2(IL-33R) were present in lungs and mediastinal lymph nodes (MedLNs), but not in broncho-alveolar lavage (BAL) fluid. Upon intranasal administration of IL-25 or IL-33, an asthma phenotype was induced, whereby ILC2s accumulated in lungs, MedLNs, and BAL fluid. After IL-25 and IL-33 administration, ILC2s constituted ∼50 and ∼80% of IL-5(+) /IL-13(+) cells in lung and BAL, respectively. Also in house dust mite-induced or ovalbumin-induced allergic asthma, the ILC2 population in lung and BAL fluid increased significantly in size and ILC2s were a major source of IL-5 or IL-13. Particularly in OVA-induced asthma, the contribution of ILC2s to the total population of intracellular IL-5(+) and IL-13(+) cells in the lung was in the same range as found for Th2 cells. We conclude that both ILC2s and Th2 cells produce large amounts of IL-5 and IL-13 that contribute to allergic airway inflammation.
Roel G J Klein Wolterink; Alex Kleinjan; Menno van Nimwegen; Ingrid Bergen; Marjolein de Bruijn; Yelvi Levani; Rudi W Hendriks
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of immunology     Volume:  42     ISSN:  1521-4141     ISO Abbreviation:  Eur. J. Immunol.     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-04-27     Completed Date:  2012-07-06     Revised Date:  2012-10-29    
Medline Journal Info:
Nlm Unique ID:  1273201     Medline TA:  Eur J Immunol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1106-16     Citation Subset:  IM    
Copyright Information:
© 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Department of Pulmonary Medicine, Erasmus MC, Rotterdam, The Netherlands.
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MeSH Terms
Antigens, Ly / immunology
Asthma / immunology*
Bronchoalveolar Lavage Fluid / immunology
Cells, Cultured
Immunity, Innate*
Interleukin-13 / biosynthesis*
Interleukin-2 Receptor alpha Subunit / immunology
Interleukin-5 / biosynthesis*
Interleukins / administration & dosage
Lung / immunology*
Lymph Nodes / immunology
Lymphocytes / immunology*
Membrane Proteins / immunology
Mice, Inbred BALB C
Mice, Inbred C57BL
Pyroglyphidae / immunology
Receptors, Interleukin / immunology
Receptors, Interleukin-7 / immunology
Th2 Cells / immunology
Reg. No./Substance:
0/Antigens, Ly; 0/D17Wsu104e protein, mouse; 0/Il1rl1 protein, mouse; 0/Il2ra protein, mouse; 0/Interleukin-13; 0/Interleukin-2 Receptor alpha Subunit; 0/Interleukin-5; 0/Interleukins; 0/Ly6a protein, mouse; 0/Membrane Proteins; 0/Receptors, Interleukin; 0/Receptors, Interleukin-7; 0/interleukin-33, mouse; 0/interleukin-7 receptor, alpha chain
Comment In:
Eur J Immunol. 2012 May;42(5):1093-6   [PMID:  22539283 ]

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