Document Detail

Pulmonary inflammatory mediators after sevoflurane and thiopentone anaesthesia in pigs.
MedLine Citation:
PMID:  14674972     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Volatile anaesthetics have been shown to affect the release of pulmonary inflammatory mediators and exacerbate pulmonary injury after experimental aspiration. Thus, in theory, volatile anaesthetics may worsen inflammatory pulmonary injury and disease. We have previously described that no significant changes in alveolar ultrastructure are seen after sevoflurane anaesthesia. However, this does not exclude any possible physiological alterations. The aim of our study was to evaluate pulmonary inflammatory mediators in bronchoalveolar lavage (BAL) after sevoflurane and thiopentone anaesthesia in pigs with intact lungs. METHODS: Sixteen pigs were randomly selected to receive either a continuous thiopentone infusion (control group, n = 8) or sevoflurane (n = 8) at 4.0% inspiratory concentration (1.5 MAC) in air for 6 h. Bronchoalveolar lavage samples were collected at the end of the study to determine pulmonary inflammatory markers. RESULTS: Compared with thiopentone anaesthesia, significant increases in BAL leukotriene C4 (LTC4), NO3-, and NO2- levels were observed after sevoflurane anaesthesia. In addition, there was a significant decrease in total blood leukocyte count in sevoflurane-treated animals. CONCLUSION: We conclude that sevoflurane increases pulmonary LTC4, NO3-, and NO2- production in pigs, indicating an inflammatory response.
R S K Takala; H R Soukka; M S Salo; O A Kirvelä; P O Kääpä; A A Rajamäki; A Riutta; R E Aantaa
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta anaesthesiologica Scandinavica     Volume:  48     ISSN:  0001-5172     ISO Abbreviation:  Acta Anaesthesiol Scand     Publication Date:  2004 Jan 
Date Detail:
Created Date:  2003-12-16     Completed Date:  2004-04-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370270     Medline TA:  Acta Anaesthesiol Scand     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  40-5     Citation Subset:  IM    
Department of Anaesthesiology and Intensive Care, Turku University Hospital, Turku, Finland.
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MeSH Terms
Anesthetics, Inhalation / pharmacology*
Anesthetics, Intravenous / pharmacology*
Bronchoalveolar Lavage Fluid / chemistry,  cytology
Cytokines / biosynthesis
Eicosanoids / biosynthesis
Inflammation Mediators / metabolism*
Leukocyte Count
Leukotriene C4 / biosynthesis
Lung / drug effects,  metabolism*
Methyl Ethers / pharmacology*
Nitric Oxide / biosynthesis
Thiopental / pharmacology*
Reg. No./Substance:
0/Anesthetics, Inhalation; 0/Anesthetics, Intravenous; 0/Cytokines; 0/Eicosanoids; 0/Inflammation Mediators; 0/Methyl Ethers; 10102-43-9/Nitric Oxide; 28523-86-6/sevoflurane; 72025-60-6/Leukotriene C4; 76-75-5/Thiopental

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