Document Detail


Pulmonary inflammation due to exercise-induced pulmonary haemorrhage in Thoroughbred colts during race training.
MedLine Citation:
PMID:  22108190     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
This study investigated the putative roles of inflammation and platelet-activating factor (PAF) in exercise-induced pulmonary haemorrhage (EIPH). Two-year-old Thoroughbred colts (n=37) were exercised on a racetrack for 5months before commencement of the study. Each colt was then exercised at 15-16m/s over 800-1000m and broncho-alveolar lavage fluid (BALF) was collected 24h later. The colts were subsequently divided into two groups on the basis of BALF analysis; an EIPH-positive group (presence of haemosiderophages, n=23) and an EIPH-negative group (absence of haemosiderophages, n=14). BALF from the EIPH-positive group had a significantly higher protein concentration (0.39±0.28 vs. 0.19±0.12mg/mL, P=0.031), higher PAF bioactivity (0.18±0.12 vs. 0.043±0.05 340:380nm ratio, P=0.042) and a higher lipid hydroperoxide concentration compared to the EIPH-negative group. There was also a lower nitrite concentration and reduced production of superoxide anion and hydrogen peroxide by alveolar macrophages in the EIPH-positive group. There was evidence of pulmonary inflammation and a decreased innate immune response of alveolar macrophages in EIPH-positive colts compared with the EIPH-negative group.
Authors:
Pedro V Michelotto; Luis A Muehlmann; Ana L Zanatta; Eloyse W R Bieberbach; Marcelo Kryczyk; Luis C Fernandes; Anita Nishiyama
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Veterinary journal (London, England : 1997)     Volume:  190     ISSN:  1532-2971     ISO Abbreviation:  Vet. J.     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9706281     Medline TA:  Vet J     Country:  England    
Other Details:
Languages:  eng     Pagination:  e3-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ltd. All rights reserved.
Affiliation:
Laboratory of Cellular Metabolism, Department of Physiology, Universidade Federal do Paraná, Curitiba, PR 81530-000, Brazil; Department of Agricultural and Environmental Sciences, Pontifícia Universidade Católica do Paraná, São José dos Pinhais, PR 80242-980, Brazil.
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