| Pulmonary inflammation due to exercise-induced pulmonary haemorrhage in Thoroughbred colts during race training. | |
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MedLine Citation:
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PMID: 22108190 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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This study investigated the putative roles of inflammation and platelet-activating factor (PAF) in exercise-induced pulmonary haemorrhage (EIPH). Two-year-old Thoroughbred colts (n=37) were exercised on a racetrack for 5months before commencement of the study. Each colt was then exercised at 15-16m/s over 800-1000m and broncho-alveolar lavage fluid (BALF) was collected 24h later. The colts were subsequently divided into two groups on the basis of BALF analysis; an EIPH-positive group (presence of haemosiderophages, n=23) and an EIPH-negative group (absence of haemosiderophages, n=14). BALF from the EIPH-positive group had a significantly higher protein concentration (0.39±0.28 vs. 0.19±0.12mg/mL, P=0.031), higher PAF bioactivity (0.18±0.12 vs. 0.043±0.05 340:380nm ratio, P=0.042) and a higher lipid hydroperoxide concentration compared to the EIPH-negative group. There was also a lower nitrite concentration and reduced production of superoxide anion and hydrogen peroxide by alveolar macrophages in the EIPH-positive group. There was evidence of pulmonary inflammation and a decreased innate immune response of alveolar macrophages in EIPH-positive colts compared with the EIPH-negative group. |
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Authors:
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Pedro V Michelotto; Luis A Muehlmann; Ana L Zanatta; Eloyse W R Bieberbach; Marcelo Kryczyk; Luis C Fernandes; Anita Nishiyama |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Veterinary journal (London, England : 1997) Volume: 190 ISSN: 1532-2971 ISO Abbreviation: Vet. J. Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9706281 Medline TA: Vet J Country: England |
Other Details:
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Languages: eng Pagination: e3-6 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Laboratory of Cellular Metabolism, Department of Physiology, Universidade Federal do Paraná, Curitiba, PR 81530-000, Brazil; Department of Agricultural and Environmental Sciences, Pontifícia Universidade Católica do Paraná, São José dos Pinhais, PR 80242-980, Brazil. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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