Document Detail


Pulmonary infiltrates in patients with haematologic malignancies: transbronchial lung biopsy increases the diagnostic yield with respect to neoplastic infiltrates and toxic pneumonitis.
MedLine Citation:
PMID:  15133629     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We retrospectively evaluated 107 fiberoptic bronchoscopies with and without transbronchial lung biopsy (TBLB) in 98 consecutive patients with haematologic malignancies and pulmonary infiltrates. Bronchoalveolar lavage (BAL) was performed in 45 and BAL plus TBLB in 62 procedures. There was no procedure-related severe haemorrhage, pneumothorax or death. Infectious aetiology was identified in 26 of 107 (24%), toxic pneumonitis in 17 of 107 (16%) and neoplastic infiltration in 9 of 107 (8.5%) episodes. Combined BAL and TBLB was significantly superior to BAL alone with respect to the diagnosis of neoplastic infiltrates (p=0.008) and toxic pneumonitis (p<0.001) and should therefore be included in the diagnostic work-up of this patient cohort.
Authors:
A Mulabecirovic; P Gaulhofer; H W Auner; H Popper; R Krause; C Hesse; H Sill
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Publication Detail:
Type:  Journal Article     Date:  2004-05-05
Journal Detail:
Title:  Annals of hematology     Volume:  83     ISSN:  0939-5555     ISO Abbreviation:  Ann. Hematol.     Publication Date:  2004 Jul 
Date Detail:
Created Date:  2004-06-01     Completed Date:  2004-09-20     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9107334     Medline TA:  Ann Hematol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  420-2     Citation Subset:  IM    
Affiliation:
Division of Rheumatology, Medical University, Auenbruggerplatz 15, 8036 Graz, Austria.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Antineoplastic Agents / adverse effects,  diagnostic use
Biopsy* / adverse effects,  methods,  statistics & numerical data
Bronchoalveolar Lavage Fluid
Bronchoscopy
Cohort Studies
Disease Progression
Female
Fiber Optic Technology
Hematologic Neoplasms / complications,  diagnosis,  pathology*
Hemorrhage / etiology,  prevention & control
Humans
Leukemic Infiltration
Lung / pathology*
Lung Diseases / diagnosis,  etiology,  pathology
Male
Middle Aged
Myelodysplastic Syndromes / complications,  diagnosis,  pathology
Platelet Transfusion
Pneumonia / chemically induced,  diagnosis,  etiology,  pathology
Predictive Value of Tests
Retrospective Studies
Chemical
Reg. No./Substance:
0/Antineoplastic Agents

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