| Pulmonary inactivation of vasopressors following cardiac operations. | |
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MedLine Citation:
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PMID: 3947173 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Vasoactive drugs were infused through catheters in the right atrium and then the left atrium of 34 patients who required either vasopressor or vasodilator support following cardiac operation to determine if the route of infusion affected the aortic blood concentration of these agents. Drugs were given through the right atrium for one hour and then the left atrium for an hour. Both central aortic and pulmonary arterial blood were assayed for drug concentrations, and hemodynamic measurements were made. Sixteen patients receiving dopamine hydrochloride through the left atrium had a 36 +/- 12% (+/- standard error of the mean) increase in aortic concentration of the drug (p less than 0.005) and a 37 +/- 14% increase in cardiac index (p less than 0.005) compared with administration through the right atrium. Seven patients receiving epinephrine showed a 59 +/- 21% increase in aortic concentration (p less than 0.05) and a 21 +/- 10% increase in cardiac index (p greater than 0.05, not significant). Eleven patients receiving sodium nitroprusside achieved a 99 +/- 25% increase in aortic concentration (p less than 0.005) and a 20 +/- 7% increase in cardiac index (p less than 0.05). In all instances, significantly higher central aortic blood concentrations were achieved during left atrial (LA) versus right atrial (RA) infusions. Changes in blood concentration of the drug between the pulmonary artery and the aorta during RA infusion suggest removal or inactivation of these drugs in the pulmonary vasculature.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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M S Hochberg; I Gielchinsky; V Parsonnet; S M Hussain; D Fisch |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Annals of thoracic surgery Volume: 41 ISSN: 0003-4975 ISO Abbreviation: Ann. Thorac. Surg. Publication Date: 1986 Feb |
Date Detail:
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Created Date: 1986-03-12 Completed Date: 1986-03-12 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 15030100R Medline TA: Ann Thorac Surg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 200-3 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Cardiac Surgical Procedures* Coronary Circulation Dopamine / administration & dosage, blood* Female Heart Atria Hemodynamics Humans Male Middle Aged Nitroprusside / blood Pulmonary Circulation Vasoconstrictor Agents / administration & dosage* |
| Chemical | |
Reg. No./Substance:
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0/Vasoconstrictor Agents; 15078-28-1/Nitroprusside |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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