Document Detail

Pulmonary hypertension and sudden death in aortic stenosis.
MedLine Citation:
PMID:  465214     Owner:  NLM     Status:  MEDLINE    
Sudden death is now an infrequent occurrence in severe aortic stenosis. However, an impressive increase in pulmonary arteriolar resistance has been found in some patients with end-stage aortic stenosis dying suddenly or deteriorating suddenly after catheterisation. Pulmonary hypertension does not seem to cause sudden death, but, in conjunction with decreased cardiac output, a critical reduction in aortic orifice area, and left ventricular failure, pulmonary hypertension identifies a population at significant risk. The rare finding of severe pulmonary hypertension in aortic stenosis should be considered an important marker for sudden death and in association with left ventricular failure may indicate an urgent need for valve replacement, regardless of the apparent clinical condition of the patient. In a small number of subjects catheterised postoperatively, increased pulmonary arteriolar resistance lessened rapidly.
M M McHenry; J Rice; H J Matlof; M D Flamm
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British heart journal     Volume:  41     ISSN:  0007-0769     ISO Abbreviation:  Br Heart J     Publication Date:  1979 Apr 
Date Detail:
Created Date:  1979-10-17     Completed Date:  1979-10-17     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0370634     Medline TA:  Br Heart J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  463-7     Citation Subset:  AIM; IM    
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MeSH Terms
Aortic Valve Stenosis / complications*,  physiopathology,  surgery
Death, Sudden / etiology*
Heart Valve Prosthesis
Hypertension, Pulmonary / complications*
Middle Aged

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