Document Detail

Pulmonary hypertension and right ventricular dysfunction in left heart disease (group 2 pulmonary hypertension).
MedLine Citation:
PMID:  23009907     Owner:  NLM     Status:  MEDLINE    
Group 2 pulmonary hypertension is most frequently caused by left heart disease, a heterogeneous set of disorders. These processes include left ventricular systolic dysfunction, left ventricular dysfunction with preserved ejection fraction and valvular (mitral and/or aortic) diseases. Left heart disease may cause passive backward transmission of pressure leading to elevated left atrial and pulmonary arterial pressures due to a myriad of processes. Increasingly, it has been recognized that some patients may develop pulmonary arterial pressure out of proportion from what is expected. This is believed to be due to increases in vasomotor tone and/or vascular remodeling. Over time patients may go on to develop progressive right ventricular dysfunction, a marker for poor prognosis. This review will explore the different characteristics of these conditions including the incidence, pathophysiology, clinical implications, prognosis and current state of available medical therapies.
Sean R Wilson; Stefano Ghio; Laura Scelsi; Evelyn M Horn
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Progress in cardiovascular diseases     Volume:  55     ISSN:  1873-1740     ISO Abbreviation:  Prog Cardiovasc Dis     Publication Date:    2012 Sep-Oct
Date Detail:
Created Date:  2012-09-26     Completed Date:  2012-12-11     Revised Date:  2013-05-02    
Medline Journal Info:
Nlm Unique ID:  0376442     Medline TA:  Prog Cardiovasc Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  104-18     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Cardiology Division, Department of Medicine, Weill Cornell Medical College, New York, NY.
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MeSH Terms
Diagnostic Imaging
Hypertension, Pulmonary* / diagnosis,  etiology,  physiopathology
Pulmonary Wedge Pressure
Severity of Illness Index
Stroke Volume
Ventricular Dysfunction, Left* / complications,  diagnosis,  physiopathology
Ventricular Dysfunction, Right* / diagnosis,  etiology,  physiopathology

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