Document Detail

Pulmonary hypertension and pregnancy.
MedLine Citation:
PMID:  19223169     Owner:  NLM     Status:  MEDLINE    
Pulmonary hypertension is defined by a mean pulmonary artery pressure of greater than 25 mmHg at rest or 30 mmHg with exercise. It can occur in association with a variety of medical conditions. The most serious elevation in pulmonary artery pressures are seen in a group of conditions that share the histological entity of plexogenic pulmonary arteriopathy. Pulmonary hypertension may be missed or diagnosed late in the course of the illness. It is associated with a poor prognosis. Pulmonary hypertension carries a significant risk to mother and child during pregnancy and pregnant women with pulmonary hypertension require careful monitoring within the framework of a multidisciplinary team. Specific targeted therapy for pulmonary hypertension may be required during pregnancy. Many agents are contraindicated because of risks of teratogenicity or secretion into breast milk. The optimum mode of delivery is not clear but early input from the high-risk obstetric anaesthesia team is essential.
B P Madden
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Publication Detail:
Type:  Journal Article; Review     Date:  2009-02-14
Journal Detail:
Title:  International journal of obstetric anesthesia     Volume:  18     ISSN:  1532-3374     ISO Abbreviation:  Int J Obstet Anesth     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-03-23     Completed Date:  2009-06-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9200430     Medline TA:  Int J Obstet Anesth     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  156-64     Citation Subset:  IM    
Department of Cardiothoracic Medicine, St George's Hospital, London, UK.
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MeSH Terms
Anesthesia, Obstetrical
Antihypertensive Agents / adverse effects,  pharmacokinetics,  therapeutic use
Delivery, Obstetric
Disease Progression
Hypertension, Pulmonary / diagnosis,  drug therapy,  physiopathology,  therapy*
Infant, Newborn
Pregnancy Complications, Cardiovascular / diagnosis,  drug therapy,  physiopathology,  therapy*
Pregnancy Outcome
Young Adult
Reg. No./Substance:
0/Antihypertensive Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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