Document Detail


Pulmonary hypertension in women.
MedLine Citation:
PMID:  21090930     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Female predominance in pulmonary arterial hypertension (PAH) has been known for several decades and recent interest in the effects of sex hormones on the development of disease has substantially increased our understanding of this epidemiologic observation. Basic science data suggest a beneficial effect of estrogens in the pulmonary vasculature both acutely and chronically, which seems to contradict the known predilection in women. Recent human and rodent data have suggested that altered levels of estrogen, differential signaling and altered metabolism of estrogens in PAH may underlie the gender difference in this disease. Studies of the effects of sex hormones on the right ventricle in animal and human disease will further aid in understanding gender differences in PAH. This article focuses on the effects of sex hormones on the pulmonary vasculature and right ventricle on both a basic science and translational level.
Authors:
Meredith E Pugh; Anna R Hemnes
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Expert review of cardiovascular therapy     Volume:  8     ISSN:  1744-8344     ISO Abbreviation:  Expert Rev Cardiovasc Ther     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-24     Completed Date:  2011-03-10     Revised Date:  2013-09-24    
Medline Journal Info:
Nlm Unique ID:  101182328     Medline TA:  Expert Rev Cardiovasc Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  1549-58     Citation Subset:  IM    
Affiliation:
Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, T1218 MCN, 1161 21st Avenue South, Nashville, TN 37232, USA. anna.r.hemnes@vanderbilt.edu.
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MeSH Terms
Descriptor/Qualifier:
Animals
Calcium Channel Blockers / therapeutic use
Estrogens / physiology*
Female
Gonadal Steroid Hormones / physiology*
Humans
Hypertension, Pulmonary / drug therapy,  physiopathology*
Phosphodiesterase Inhibitors / therapeutic use
Prostaglandins I / therapeutic use
Pulmonary Artery / physiopathology*
Receptors, Endothelin / antagonists & inhibitors
Sex Factors
Ventricular Dysfunction, Right / physiopathology
Ventricular Remodeling
Grant Support
ID/Acronym/Agency:
K08 HL093363/HL/NHLBI NIH HHS; K08 HL093363-02/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Calcium Channel Blockers; 0/Estrogens; 0/Gonadal Steroid Hormones; 0/Phosphodiesterase Inhibitors; 0/Prostaglandins I; 0/Receptors, Endothelin
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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