| Pulmonary hypertension in women. | |
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MedLine Citation:
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PMID: 21090930 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Female predominance in pulmonary arterial hypertension (PAH) has been known for several decades and recent interest in the effects of sex hormones on the development of disease has substantially increased our understanding of this epidemiologic observation. Basic science data suggest a beneficial effect of estrogens in the pulmonary vasculature both acutely and chronically, which seems to contradict the known predilection in women. Recent human and rodent data have suggested that altered levels of estrogen, differential signaling and altered metabolism of estrogens in PAH may underlie the gender difference in this disease. Studies of the effects of sex hormones on the right ventricle in animal and human disease will further aid in understanding gender differences in PAH. This article focuses on the effects of sex hormones on the pulmonary vasculature and right ventricle on both a basic science and translational level. |
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Authors:
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Meredith E Pugh; Anna R Hemnes |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Expert review of cardiovascular therapy Volume: 8 ISSN: 1744-8344 ISO Abbreviation: Expert Rev Cardiovasc Ther Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-24 Completed Date: 2011-03-10 Revised Date: 2011-09-13 |
Medline Journal Info:
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Nlm Unique ID: 101182328 Medline TA: Expert Rev Cardiovasc Ther Country: England |
Other Details:
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Languages: eng Pagination: 1549-58 Citation Subset: IM |
Affiliation:
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Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, T1218 MCN, 1161 21st Avenue South, Nashville, TN 37232, USA. anna.r.hemnes@vanderbilt.edu. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Calcium Channel Blockers / therapeutic use Estrogens / physiology* Female Gonadal Steroid Hormones / physiology* Humans Hypertension, Pulmonary / drug therapy, physiopathology* Phosphodiesterase Inhibitors / therapeutic use Prostaglandins I / therapeutic use Pulmonary Artery / physiopathology* Receptors, Endothelin / antagonists & inhibitors Sex Factors Ventricular Dysfunction, Right / physiopathology Ventricular Remodeling |
| Grant Support | |
ID/Acronym/Agency:
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K08 HL093363-02/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Calcium Channel Blockers; 0/Estrogens; 0/Gonadal Steroid Hormones; 0/Phosphodiesterase Inhibitors; 0/Prostaglandins I; 0/Receptors, Endothelin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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