| Pulmonary hypertension in sickle-cell disease: comorbidities and echocardiographic findings. | |
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MedLine Citation:
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PMID: 17505130 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Our aim is to determine comorbidities associated with pulmonary hypertension (PHT) in clinically stable sickle-cell disease (SCD) patients and to evaluate left ventricular (LV) and right ventricular (RV) function in those patients. METHODS: Echocardiography was performed in 87 SCD patients that were divided into group I (without PHT) and group II (with PHT). Both groups were compared with healthy controls. RESULTS: A history of retinopathy and leg ulcer was more frequent in group II than group I (p < 0.01). Haemoglobin levels were lower (p < 0.05), whereas blood urea nitrogen, lactate dehydrogenase and total bilirubin levels were higher in group II (p < 0.01). Although group II patients had larger LV end-diastolic, LV end-systolic and RV diastolic diameters compared with group I patients and controls (p < 0.05), LV ejection fraction was similar in the three groups. The mitral peak early diastolic inflow velocity to peak late diastolic inflow velocity (E/A) ratio was similar in group I, group II and the control group. The tricuspid E/A ratio was lower in group II than group I and controls (p < 0.05). CONCLUSION: End organ damage occurs more often and haemolysis is severer in SCD patients with PHT than SCD patients without PHT. Although LV systolic and diastolic function is well preserved, RV diastolic function is disturbed in those patients with PHT. |
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Authors:
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Ferit Akgül; Fatih Yalçin; Ergün Seyfeli; Edip Uçar; Sinem Karazincir; Ali Balci; Edip Gali |
Publication Detail:
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Type: Journal Article Date: 2007-05-14 |
Journal Detail:
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Title: Acta haematologica Volume: 118 ISSN: 1421-9662 ISO Abbreviation: Acta Haematol. Publication Date: 2007 |
Date Detail:
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Created Date: 2007-06-28 Completed Date: 2007-07-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0141053 Medline TA: Acta Haematol Country: Switzerland |
Other Details:
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Languages: eng Pagination: 53-60 Citation Subset: IM |
Copyright Information:
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Copyright 2007 S. Karger AG, Basel. |
Affiliation:
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Department of Cardiology, Faculty of Medicine, Mustafa Kemal University, Antakya, Turkey. feritakgul1@yahoo.ca |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Age Distribution Anemia, Sickle Cell / epidemiology*, ultrasonography* Case-Control Studies Child Cohort Studies Comorbidity Echocardiography, Transesophageal Female Humans Hypertension, Pulmonary / epidemiology*, ultrasonography* Incidence Male Probability Prognosis Reference Values Risk Assessment Severity of Illness Index Sex Distribution Stroke Volume Survival Rate Ultrasonography, Doppler, Color Ventricular Dysfunction, Left / epidemiology, ultrasonography |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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