Document Detail


Pulmonary hypertension in sickle cell disease.
MedLine Citation:
PMID:  15501204     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Recurrent vaso-occlusive episodes lead to progressive end-organ damage in patients with sickle cell disease. We sought to determine the prevalence of pulmonary hypertension in adult patients with sickle cell disease and to identify factors associated with this life-threatening complication. METHODS: Sixty patients (> or =18 years of age; mean [+/- SD] age, 37 +/- 13 years) followed at a University Medical Center were evaluated. They were selected by a systematic sampling of patients presenting to the clinic for routine follow-up visits. All enrolled subjects underwent a clinical examination, Doppler echocardiography, pulmonary function tests, and hematologic tests during a single visit. Pulmonary hypertension was defined using an age- and body mass index-adjusted nomogram. RESULTS: The prevalence of pulmonary hypertension was 30% (18/60). Ten patients had mild pulmonary hypertension (up to 44 mm Hg), 5 had moderate pulmonary hypertension (45 to 74 mm Hg), and 2 had severe pulmonary hypertension (> or =75 mm Hg). In a logistic regression model, both lower fetal hemoglobin level and lower systolic blood pressure were associated with the presence of pulmonary hypertension. CONCLUSION: We found that the prevalence of pulmonary hypertension in adult patients with sickle cell disease was substantial, particularly in those with lower levels of fetal hemoglobin and lower systolic blood pressure.
Authors:
Kenneth I Ataga; Namita Sood; Guy De Gent; Eileen Kelly; Ashley G Henderson; Susan Jones; Dell Strayhorn; Alice Lail; Susan Lieff; Eugene P Orringer
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of medicine     Volume:  117     ISSN:  0002-9343     ISO Abbreviation:  Am. J. Med.     Publication Date:  2004 Nov 
Date Detail:
Created Date:  2004-10-25     Completed Date:  2004-11-23     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0267200     Medline TA:  Am J Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  665-9     Citation Subset:  AIM; IM    
Affiliation:
Department of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA. kataga@med.unc.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Anemia, Sickle Cell / complications*,  diagnosis,  epidemiology
Cross-Sectional Studies
Echocardiography, Doppler
Female
Hematologic Tests
Humans
Hypertension, Pulmonary / diagnosis,  epidemiology,  etiology*
Logistic Models
Male
Prevalence
Respiratory Function Tests
Grant Support
ID/Acronym/Agency:
HL7076/HL/NHLBI NIH HHS; RR00046/RR/NCRR NIH HHS; RR17059/RR/NCRR NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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