| Pulmonary hypertension in a patient with Schmidt syndrome. | |
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MedLine Citation:
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PMID: 19857444 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We describe a 26-year-old patient with long-standing autoimmune hypothyroidism. She was doing well until she developed Addisonian crisis accompanied by severe metabolic acidosis, hypoglycemia, hypomagnesemia, and hypokalemia. Subsequently she developed a life-threatening cardiac arrhythmia due to QT prolongation secondary to electrolyte imbalance. The association of autoimmune hypothyroidism and adrenal insufficiency in our patient suggests the diagnosis of autoimmune polyglandular syndrome type II or Schmidt syndrome. An echocardiography that was performed detected pulmonary hypertension without apparent cardiac or lung pathology. The association of pulmonary hypertension and Schmidt syndrome is rare and may be explained by a generalized immune activation leading to pulmonary endothelial damage or dysfunction. |
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Authors:
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Walid R Saliba; Wasseem Rock; Mazen Elias |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The American journal of emergency medicine Volume: 27 ISSN: 1532-8171 ISO Abbreviation: Am J Emerg Med Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-10-27 Completed Date: 2009-12-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8309942 Medline TA: Am J Emerg Med Country: United States |
Other Details:
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Languages: eng Pagination: 1025.e1-2 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine C, Ha'emeK Medical Center, Afula, Affiliated to the Technion-Israel Institute of Technology, Faculty of Medicine, Haifa, Israel. salibuss@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Female Humans Hypertension, Pulmonary / etiology*, therapy Polyendocrinopathies, Autoimmune / complications*, therapy |
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