Document Detail

Pulmonary hypertension in children with sickle cell disease.
MedLine Citation:
PMID:  21510733     Owner:  NLM     Status:  In-Data-Review    
Pulmonary hypertension and cor pulmonale have long been known to be complications of sickle cell disease, thought mostly to affect the adult population. Recently, pediatric studies in sickle cell patients have uncovered a similar prevalence of elevated tricuspid regurgitation jet velocities, a finding consistent with increased right-sided pressures, when compared with adult counterparts. Implications on mortality to date, while significant in the adult sickle cell population, appear to be unsubstantiated in children and adolescents. We review the recent literature in an attempt to discuss the prevalence, etiology and implications of an elevated tricuspid regurgitation jet velocity in pediatric sickle cell patients. We also suggest screening, diagnostics, treatment and follow-up plans that may improve the disease burden of pulmonary hypertension in both pediatric and adult sickle cell populations.
Warren A Zuckerman; Erika B Rosenzweig
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Expert review of respiratory medicine     Volume:  5     ISSN:  1747-6356     ISO Abbreviation:  Expert Rev Respir Med     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-04-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101278196     Medline TA:  Expert Rev Respir Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  233-43     Citation Subset:  IM    
Columbia University Medical Center, 3959 Broadway, New York, NY 10032, USA.
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