Document Detail

Pulmonary hypertension and hypoxemia in obstructive sleep apnea syndrome.
MedLine Citation:
PMID:  8306039     Owner:  NLM     Status:  MEDLINE    
To determine whether pulmonary hypertension (PH) can occur in obstructive sleep apnea syndrome (OSAS) in the absence of lung or primary cardiac disease, we studied 27 patients (26 males, mean age 49 +/- 10 yr) with OSAS (respiratory disturbance index [RDI] > 10 events/h) in whom clinically significant lung or cardiac diseases were excluded. Pulsed Doppler measurements of pulmonary hemodynamics, pulmonary function tests, arterial blood gas analysis, and polysomnography were performed. A total of 11 OSAS patients (41%) were found to have pulmonary hypertension. The levels of PH were relatively mild (Ppa < or = 26 mm Hg). There were no differences between PH and non-PH patients in body mass index (BMI), smoking history, or lung function. PH patients were more hypoxemic when awake than non-PH patients (PaO2 = 72.2 +/- 7.6 versus 77.6 +/- 7.3 mm Hg, respectively; p < 0.05) but did not differ in severity of sleep apnea (RDI = 51.9 +/- 25.1 versus 56.8 +/- 26.2 events/h, respectively; p = NS) or indices of sleep desaturation. The hypoxemia in PH patients could not be explained by impairment of lung function, greater body mass, or a higher prevalence of smoking, and PaO2 in the study population was significantly correlated with Ppa (r = -0.46, p < 0.02) but not with FEV1 or BMI. We conclude that lung disease is not a prerequisite for PH in OSAS.(ABSTRACT TRUNCATED AT 250 WORDS)
D Sajkov; R J Cowie; A T Thornton; H A Espinoza; R D McEvoy
Related Documents :
18627329 - Pharmacotherapy in patients with idiopathic pulmonary fibrosis.
7874809 - Scintigraphic appearances in patients with pulmonary infection and lung scintigrams of ...
3469849 - The quality and diagnostic outcome of postbronchoscopic sputum.
7255939 - Intrapulmonary gas transport of he and sf6 in healthy subjects and patients with chroni...
15373309 - Long-term non-invasive positive pressure ventilation among cystic fibrosis patients awa...
18640019 - Anca-associated lung fibrosis: analysis of 17 patients.
21383629 - Generic abilhand questionnaire can measure manual ability across a variety of motor imp...
7851559 - Malignant peripheral nerve sheath tumors in patients with and without neurofibromatosis.
308809 - Immunological abnormalities in bronchiectasis with chronic bronchial suppuration.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of respiratory and critical care medicine     Volume:  149     ISSN:  1073-449X     ISO Abbreviation:  Am. J. Respir. Crit. Care Med.     Publication Date:  1994 Feb 
Date Detail:
Created Date:  1994-03-17     Completed Date:  1994-03-17     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9421642     Medline TA:  Am J Respir Crit Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  416-22     Citation Subset:  AIM; IM    
Department of Thoracic Medicine, Royal Adelaide Hospital, South Australia, Australia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Anoxia / etiology*
Echocardiography, Doppler
Hypertension, Pulmonary / diagnosis,  etiology*,  physiopathology
Middle Aged
Pulmonary Circulation / physiology*
Respiratory Function Tests
Sleep Apnea Syndromes / complications*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Ventilatory response to exercise in men and women 55 to 86 years of age.
Next Document:  Pulmonary vascular abnormalities and ventilation-perfusion relationships in mild chronic obstructive...