Document Detail


Pulmonary hypertension following L-lysine ibuprofen therapy in a preterm infant with patent ductus arteriosus.
MedLine Citation:
PMID:  16785458     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Patent ductus arteriosus is one of the most common congenital abnormalities found in premature infants. Ibuprofen, a nonsteroidal drug that is commonly used as an antipyretic, analgesic and anti-inflammatory agent, is also used to induce closure of symptomatic patent ductus arteriosus in preterm infants. Recently, we gave L-lysine ibuprofen to a preterm infant with respiratory distress to induce closure of a patent ductus arteriosus, and the infant experienced pulmonary hypertension. Only 3 cases of pulmonary hypertension following early administration of an ibuprofen solution buffered with tromethamine have previously been reported. However, this severe side effect has never been observed in multicentre, randomized, double-blind controlled trials, nor in recent reviews or meta-analyses of L-lysine ibuprofen use.
Authors:
Carlo Bellini; Francesco Campone; Giovanni Serra
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne     Volume:  174     ISSN:  1488-2329     ISO Abbreviation:  CMAJ     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-06-20     Completed Date:  2006-07-11     Revised Date:  2013-06-07    
Medline Journal Info:
Nlm Unique ID:  9711805     Medline TA:  CMAJ     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  1843-4     Citation Subset:  AIM; IM    
Affiliation:
Neonatal Intensive Care Unit, Department of Pediatrics, University of Genoa, Gaslini Institute, Genoa, Italy. carlobellini@ospedale-gaslini.ge.it
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MeSH Terms
Descriptor/Qualifier:
Anoxia / chemically induced
Anti-Inflammatory Agents, Non-Steroidal / adverse effects*,  therapeutic use
Ductus Arteriosus, Patent / drug therapy*
Fatal Outcome
Humans
Hypertension, Pulmonary / chemically induced*
Ibuprofen / adverse effects*,  chemistry,  therapeutic use
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases / drug therapy*
Lysine
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 15687-27-1/Ibuprofen; 56-87-1/Lysine
Comments/Corrections
Comment In:
CMAJ. 2006 Jun 20;174(13):1855   [PMID:  16785460 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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