Document Detail

Pulmonary hypertension due to isolated metastatic squamous cell carcinoma thromboemboli.
MedLine Citation:
PMID:  16412689     Owner:  NLM     Status:  MEDLINE    
Pulmonary hypertension as the initial presentation of occult malignancy is extremely rare. The differential diagnosis of pulmonary hypertension due to arterial tumour embolism is often overlooked and deserves contemplation. Our case report details the presentation of cardiorespiratory decompensation from an assumed classic saddle pulmonary embolus in a previously fit, well 80-year-old gentleman. The patient underwent successful pulmonary thromboendarterectomy, however, intraoperatively the specimen was noted to be atypical. This resulted in the surprising definitive diagnosis of thromboembolic pulmonary hypertension secondary to laminated thrombi of metastatic squamous cell tumour emboli. The site of tumour origin was however not histologically apparent and was unable to be elucidated on extensive further investigation. Post-operatively the patient had considerable subjective and functional improvement returning to activities of daily living. He however passed away some 9 months later.
Michael K Wilson; Emily K Granger; Veronica A Preda
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2006-01-18
Journal Detail:
Title:  Heart, lung & circulation     Volume:  15     ISSN:  1443-9506     ISO Abbreviation:  Heart Lung Circ     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-03-31     Completed Date:  2007-07-17     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  100963739     Medline TA:  Heart Lung Circ     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  143-5     Citation Subset:  IM    
Department of Cardiothoracic Surgery, Royal Prince Alfred Hospital, Suite 304, 100 Carillon Avenue Newtown, Camperdown, Sydney, NSW 2042, Australia.
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MeSH Terms
Aged, 80 and over
Arterial Occlusive Diseases / diagnosis*,  surgery
Diagnosis, Differential
Dyspnea / diagnosis
Hypertension, Pulmonary / diagnosis*,  etiology,  surgery
Neoplasms, Squamous Cell / diagnosis*,  secondary
Neoplastic Cells, Circulating
Pulmonary Embolism / complications,  diagnosis*,  surgery
Thromboembolism / complications,  diagnosis*,  surgery

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