Document Detail

Pulmonary hypertension and antiphospholipid antibody in a patient with Sjögren's syndrome.
MedLine Citation:
PMID:  7718958     Owner:  NLM     Status:  MEDLINE    
A 57-year-old female patient with Sjögren's syndrome was complicated with pulmonary hypertension (PH) and antiphospholipid antibody (aPL). She had a history of fetal losses, deep vein thrombosis and chronic thyroiditis. On admission, severe pulmonary hypertension, thrombocytopenia, lupus anticoagulant and a decreased level of protein C were found. Pulmonary artery perfusion scintigram revealed multiple defects. She died suddenly despite an intensive therapy. Intimal proliferation with angiomatoid lesions in small pulmonary arteries was observed by autopsy. Since a close relationship between PH and aPL in connective tissue disease is found, it is important to carefully analyze the antiphospholipid antibodies in patients with PH.
S Biyajima; T Osada; H Daidoji; T Hisaoka; Y Sakakibara; J Tajima; M Nakazawa; H Kuroda; S Kobayashi
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Internal medicine (Tokyo, Japan)     Volume:  33     ISSN:  0918-2918     ISO Abbreviation:  Intern. Med.     Publication Date:  1994 Dec 
Date Detail:
Created Date:  1995-05-25     Completed Date:  1995-05-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9204241     Medline TA:  Intern Med     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  768-72     Citation Subset:  IM    
Department of Medicine, Koutou Hospital, Tokyo.
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MeSH Terms
Antiphospholipid Syndrome / complications*,  diagnosis
Fatal Outcome
Hypertension, Pulmonary / complications*,  diagnosis
Middle Aged
Pulmonary Embolism / complications,  diagnosis
Sjogren's Syndrome / complications*,  diagnosis

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