| Pulmonary hemorrhage as a clinical manifestation of hemolytic-uremic syndrome associated with mitomycin C therapy. | |
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MedLine Citation:
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PMID: 8222875 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Mitomycin C (MMC) is an alkylating agent that has been recently associated with the hemolytic-uremic syndrome (HUS). Pulmonary impairment in the HUS is rarely reported in the literature, and no reports of pulmonary hemorrhage, as a clinical feature of the HUS, have been documented. We describe two women who developed HUS after MMC therapy and presented massive pulmonary bleeding. Pulmonary hemorrhage is an uncommon feature in the HUS, and seems to appear especially in the HUS associated with MMC therapy. It is extremely resistant to standard treatment, and confers a poor prognosis for this disease. |
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Authors:
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R Torra; E Poch; A Torras; J A Bombí; L Revert |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Chemotherapy Volume: 39 ISSN: 0009-3157 ISO Abbreviation: Chemotherapy Publication Date: 1993 Nov-Dec |
Date Detail:
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Created Date: 1993-12-01 Completed Date: 1993-12-01 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0144731 Medline TA: Chemotherapy Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 453-6 Citation Subset: IM |
Affiliation:
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Nephrology Service, Hospital Clínic, Barcelona, Spain. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenocarcinoma
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drug therapy Adult Cecal Neoplasms / drug therapy Colonic Neoplasms / drug therapy Female Hemolytic-Uremic Syndrome / chemically induced*, complications* Hemorrhage / etiology* Humans Lung Diseases / etiology* Middle Aged Mitomycin / adverse effects* |
| Chemical | |
Reg. No./Substance:
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50-07-7/Mitomycin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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