Document Detail

Pulmonary hamartomas: CT pixel analysis for fat attenuation using radiologic-pathologic correlation.
MedLine Citation:
PMID:  24119266     Owner:  NLM     Status:  Publisher    
INTRODUCTION: To assess the accuracy of CT pixel analysis for fat attenuation in pulmonary hamartomas.
METHODS: Retrospective review identified 32 patients in three separate groups; pathologically proven hamartoma (n = 11), hamartoma diagnosed on imaging (n = 9) and a control group (n = 14) of pathology-proven non-hamartomatous smoothly marginated solitary pulmonary nodules. All lesions were assessed using: visual assessment for fat, pixel analysis of the inner 2/3rds and mean attenuation of the entire lesion, using an internal reference for fat. Fat percentages on CT and at histology were compared.
RESULTS: Visual assessment for macroscopic fat was the most reliable method for diagnosing pulmonary hamartoma. Combining percentage of fat-attenuation pixels in the inner 2/3rds of the lesion improved specificity to 100%. Mean attenuation or pixel analysis in isolation were not helpful in lesional characterization.
CONCLUSION: Combining percentage fat-attenuating pixels in the inner 2/3rds with visual assessment for macroscopic fat improves specificity for diagnosing pulmonary hamartomas.
Tadhg Gleeson; Rennae Thiessen; Ailish Hannigan; Darra Murphy; John C English; John R Mayo
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-6-4
Journal Detail:
Title:  Journal of medical imaging and radiation oncology     Volume:  57     ISSN:  1754-9485     ISO Abbreviation:  J Med Imaging Radiat Oncol     Publication Date:  2013 Oct 
Date Detail:
Created Date:  2013-10-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101469340     Medline TA:  J Med Imaging Radiat Oncol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  534-543     Citation Subset:  -    
Copyright Information:
© 2013 The Royal Australian and New Zealand College of Radiologists.
Wexford General Hospital, Wexford, Ireland.
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