Document Detail


Pulmonary haemorrhage in a 6-year-old boy with Henoch-Schönlein purpura.
MedLine Citation:
PMID:  11529643     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Henoch-Schönlein purpura (HSP) is the most common vasculitis in children. It is a multisystemic disease but pulmonary haemorrhage is extremely rare. We present the case of a 6-year-old boy with Henoch-Schönlein purpura, pulmonary haemorrhage and severe renal involvement. The patient responded to a combination of intravenous methylprednisolone and cyclophosphamide. A review of the literature revealed that young age may be a good prognostic sign and that immunosuppressive drugs and supportive management are essential in the treatment. Renal biopsy is helpful in the differential diagnosis of HSP-mimicking pulmonary vasculitic syndromes. Combining cyclophosphamide with glucocorticoids may improve the outcome in severe HSP cases with pulmonary haemorrhage.
Authors:
N Besbas; A Duzova; R Topaloglu; F Gok; F Ozaltin; S Ozen; A Bakkaloglu
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Clinical rheumatology     Volume:  20     ISSN:  0770-3198     ISO Abbreviation:  Clin. Rheumatol.     Publication Date:  2001  
Date Detail:
Created Date:  2001-08-31     Completed Date:  2002-01-29     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8211469     Medline TA:  Clin Rheumatol     Country:  Belgium    
Other Details:
Languages:  eng     Pagination:  293-6     Citation Subset:  IM    
Affiliation:
Hacettepe University Faculty of Medicine, Ankara, Turkey.
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MeSH Terms
Descriptor/Qualifier:
Child
Cyclophosphamide / administration & dosage*
Drug Therapy, Combination
Follow-Up Studies
Hemorrhage / diagnosis,  drug therapy,  etiology*
Humans
Infusions, Intravenous
Kidney Failure / diagnosis,  etiology*,  therapy
Lung Diseases / diagnosis,  drug therapy,  etiology*
Male
Methylprednisolone / administration & dosage*
Purpura, Schoenlein-Henoch / complications*,  diagnosis,  drug therapy*
Renal Dialysis
Severity of Illness Index
Treatment Outcome
Chemical
Reg. No./Substance:
50-18-0/Cyclophosphamide; 83-43-2/Methylprednisolone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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