| Pulmonary haemorrhage in a 6-year-old boy with Henoch-Schönlein purpura. | |
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MedLine Citation:
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PMID: 11529643 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Henoch-Schönlein purpura (HSP) is the most common vasculitis in children. It is a multisystemic disease but pulmonary haemorrhage is extremely rare. We present the case of a 6-year-old boy with Henoch-Schönlein purpura, pulmonary haemorrhage and severe renal involvement. The patient responded to a combination of intravenous methylprednisolone and cyclophosphamide. A review of the literature revealed that young age may be a good prognostic sign and that immunosuppressive drugs and supportive management are essential in the treatment. Renal biopsy is helpful in the differential diagnosis of HSP-mimicking pulmonary vasculitic syndromes. Combining cyclophosphamide with glucocorticoids may improve the outcome in severe HSP cases with pulmonary haemorrhage. |
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Authors:
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N Besbas; A Duzova; R Topaloglu; F Gok; F Ozaltin; S Ozen; A Bakkaloglu |
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Publication Detail:
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Type: Case Reports; Journal Article; Review |
Journal Detail:
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Title: Clinical rheumatology Volume: 20 ISSN: 0770-3198 ISO Abbreviation: Clin. Rheumatol. Publication Date: 2001 |
Date Detail:
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Created Date: 2001-08-31 Completed Date: 2002-01-29 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 8211469 Medline TA: Clin Rheumatol Country: Belgium |
Other Details:
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Languages: eng Pagination: 293-6 Citation Subset: IM |
Affiliation:
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Hacettepe University Faculty of Medicine, Ankara, Turkey. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Child Cyclophosphamide / administration & dosage* Drug Therapy, Combination Follow-Up Studies Hemorrhage / diagnosis, drug therapy, etiology* Humans Infusions, Intravenous Kidney Failure / diagnosis, etiology*, therapy Lung Diseases / diagnosis, drug therapy, etiology* Male Methylprednisolone / administration & dosage* Purpura, Schoenlein-Henoch / complications*, diagnosis, drug therapy* Renal Dialysis Severity of Illness Index Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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50-18-0/Cyclophosphamide; 83-43-2/Methylprednisolone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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