Document Detail

Pulmonary haemodynamic changes in patients with severe COPD.
MedLine Citation:
PMID:  18657066     Owner:  NLM     Status:  MEDLINE    
Worsening gas exchange during exercise and during exacerbations of COPD contributes to systemic hypoxaemia and reduces quality of life. However, pulmonary haemodynamic changes under such conditions are not well understood. Right heart catheterization was performed in six patients with severe COPD (%FEV(1) < 50%) during rest, exercise and during an exacerbation. Pulmonary artery pressure (Ppa) was slightly elevated at rest. The Ppa, as well as pulmonary artery wedge pressure (Pawp) and cardiac index were significantly increased during bicycle ergometer exercise. In contrast, pulmonary vascular resistance increased significantly during an exacerbation accompanied by a slightly increased Ppa. Supplemental oxygen resulted in significant decreases in Ppa and Pawp during exercise and Ppa during exacerbations. In patients with COPD, haemodynamic changes in the pulmonary circulation may differ during exercise and with exacerbations. Supplementary oxygen is beneficial and associated with reductions in pulmonary arterial pressures.
Masayuki Hanaoka; Gen Ideura; Michiko Ito; Kazuhisa Urushihata; Tomonobu Koizumi; Keisaku Fujimoto; Keishi Kubo
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Publication Detail:
Type:  Journal Article     Date:  2008-07-24
Journal Detail:
Title:  Respirology (Carlton, Vic.)     Volume:  13     ISSN:  1440-1843     ISO Abbreviation:  Respirology     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-09-24     Completed Date:  2009-02-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9616368     Medline TA:  Respirology     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  919-22     Citation Subset:  IM    
First Department of Medicine, Shinshu University School of Medicine, Matsumoto, Japan.
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MeSH Terms
Disease Progression
Forced Expiratory Volume
Heart Catheterization
Hypertension, Pulmonary / epidemiology
Oxygen Consumption
Pulmonary Artery / physiopathology
Pulmonary Circulation / physiology*
Pulmonary Disease, Chronic Obstructive / epidemiology,  physiopathology*
Pulmonary Gas Exchange
Vascular Resistance

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