| Pulmonary ground-glass opacity (GGO) lesions-large size and a history of lung cancer are risk factors for growth. | |
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MedLine Citation:
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PMID: 18978558 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Ground-glass opacity (GGO) of the lung is being frequently detected by thin section computed tomography scan. However, the long term management of detected GGO is still unclear. To establish follow-up plans, we performed the clinical and radiological review to identify the factors that are closely associated with GGO growth. METHODS: We retrospectively analyzed computed tomography images of 125 GGOs that were stable for 3 months between 1999 and 2006 at the Cancer Institute Hospital, Tokyo. To identify factors that affect the roentgenological growth, the time to GGO growth curve by Kaplan-Meyer method was evaluated in terms of gender, age, smoking, initial size, existence of a solid part, GGO density, location, multiplicity, and lung cancer history by univariate and multivariate analyses. RESULTS: The median observation period was 1048 days (177-3269) and 26 of 125 GGOs (21%) grew. The estimated growth population for 5 years was 30%. The growth was more frequently seen in the elderly (p = 0.017), in part-solid GGO (p < 0.01) and in GGO of larger than 10 mm (p < 0.01, logrank test). By multivariate analysis, initial size (p < 0.01, Cox's model) and history of lung cancer (p = 0.017, logistic model) were independent factors that were significantly associated with GGO growth. Fifty GGOs that were 10 mm or smaller and without a lung cancer history did not grow within 3.5 years. CONCLUSIONS: After initial management and 3 month follow-up, larger size (more than 10 mm) and a history of lung cancer are risk factors for GGO growth, and therefore should be considered when making a follow-up plan. |
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Authors:
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Miyako Hiramatsu; Takuya Inagaki; Tomoya Inagaki; Yoshio Matsui; Yukitoshi Satoh; Sakae Okumura; Yuichi Ishikawa; Etsuo Miyaoka; Ken Nakagawa |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer Volume: 3 ISSN: 1556-1380 ISO Abbreviation: J Thorac Oncol Publication Date: 2008 Nov |
Date Detail:
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Created Date: 2008-11-03 Completed Date: 2009-01-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101274235 Medline TA: J Thorac Oncol Country: United States |
Other Details:
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Languages: eng Pagination: 1245-50 Citation Subset: IM |
Affiliation:
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Department of Thoracic Surgical Oncology, Cancer Institute Hospital of Japanese Foundation for Cancer Research, Koto-ku, Tokyo, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Female Humans Lung / pathology* Lung Neoplasms / pathology*, radiography Male Middle Aged Prognosis Retrospective Studies Risk Factors Tomography, X-Ray Computed |
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