Document Detail

Pulmonary gangliocytic paraganglioma: case report and comparative immunohistochemical study of related neuroendocrine neoplasms.
MedLine Citation:
PMID:  11342785     Owner:  NLM     Status:  MEDLINE    
The authors report a case of gangliocytic paraganglioma of the lung, which has not yet been described in a pulmonary neoplasm. A 75-year-old man underwent right middle and lower lobe lobectomy. A slightly yellowish mass was located at the bifurcation between the lower and middle lobe bronchus, protruding into the truncus intermedius. The neoplastic cells were composed of three cellular elements: uniform endocrine cells in a Zellballen arrangement, large ganglion-like cells within the nests of endocrine cells, and spindle-shaped cells arranged in streams to surround the nests. Each component exhibited the characteristic immunohistochemical properties, which were similar to those of the corresponding neuroendocrine neoplasms: Endocrine cells were positive for CAM 5.2, chromogranin A, and synaptophysin, like carcinoid tumor; ganglion-like cells were positive only for neurofilament, like ganglioneuroma; and spindle-shaped cells were positive for neurofilament and S-100 protein, like paraganglioma. These results agreed with those in gangliocytic paraganglioma of the duodenum. Pulmonary gangliocytic paraganglioma is similar to that in the duodenum, and is a hamartomatous proliferation of epithelial endocrine and neuronal cells of the bronchus.
M Hironaka; M Fukayama; N Takayashiki; K Saito; Y Sohara; N Funata
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Publication Detail:
Type:  Case Reports; Comparative Study; Journal Article    
Journal Detail:
Title:  The American journal of surgical pathology     Volume:  25     ISSN:  0147-5185     ISO Abbreviation:  Am. J. Surg. Pathol.     Publication Date:  2001 May 
Date Detail:
Created Date:  2001-05-08     Completed Date:  2001-05-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7707904     Medline TA:  Am J Surg Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  688-93     Citation Subset:  IM    
Department of Pathology, Jichi Medical School, Tochigi, Japan.
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MeSH Terms
Biological Markers
Chromogranin A
Chromogranins / analysis
Immunoenzyme Techniques
Keratins / analysis
Lung Neoplasms / chemistry,  pathology*,  radiography,  surgery
Neoplasm Proteins / analysis
Neurofilament Proteins / analysis
Paraganglioma / chemistry,  pathology*,  radiography,  surgery
Radiography, Thoracic
S100 Proteins / analysis
Synaptophysin / analysis
Tomography, X-Ray Computed
Tumor Markers, Biological / analysis
Reg. No./Substance:
0/Biological Markers; 0/CAM 5.2 antigen; 0/Chromogranin A; 0/Chromogranins; 0/Neoplasm Proteins; 0/Neurofilament Proteins; 0/S100 Proteins; 0/Synaptophysin; 0/Tumor Markers, Biological; 108688-71-7/neurofilament protein H; 68238-35-7/Keratins

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