| Pulmonary gangliocytic paraganglioma: case report and comparative immunohistochemical study of related neuroendocrine neoplasms. | |
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MedLine Citation:
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PMID: 11342785 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The authors report a case of gangliocytic paraganglioma of the lung, which has not yet been described in a pulmonary neoplasm. A 75-year-old man underwent right middle and lower lobe lobectomy. A slightly yellowish mass was located at the bifurcation between the lower and middle lobe bronchus, protruding into the truncus intermedius. The neoplastic cells were composed of three cellular elements: uniform endocrine cells in a Zellballen arrangement, large ganglion-like cells within the nests of endocrine cells, and spindle-shaped cells arranged in streams to surround the nests. Each component exhibited the characteristic immunohistochemical properties, which were similar to those of the corresponding neuroendocrine neoplasms: Endocrine cells were positive for CAM 5.2, chromogranin A, and synaptophysin, like carcinoid tumor; ganglion-like cells were positive only for neurofilament, like ganglioneuroma; and spindle-shaped cells were positive for neurofilament and S-100 protein, like paraganglioma. These results agreed with those in gangliocytic paraganglioma of the duodenum. Pulmonary gangliocytic paraganglioma is similar to that in the duodenum, and is a hamartomatous proliferation of epithelial endocrine and neuronal cells of the bronchus. |
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Authors:
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M Hironaka; M Fukayama; N Takayashiki; K Saito; Y Sohara; N Funata |
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Publication Detail:
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Type: Case Reports; Comparative Study; Journal Article |
Journal Detail:
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Title: The American journal of surgical pathology Volume: 25 ISSN: 0147-5185 ISO Abbreviation: Am. J. Surg. Pathol. Publication Date: 2001 May |
Date Detail:
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Created Date: 2001-05-08 Completed Date: 2001-05-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7707904 Medline TA: Am J Surg Pathol Country: United States |
Other Details:
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Languages: eng Pagination: 688-93 Citation Subset: IM |
Affiliation:
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Department of Pathology, Jichi Medical School, Tochigi, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Biological Markers Chromogranin A Chromogranins / analysis Humans Immunoenzyme Techniques Keratins / analysis Lung Neoplasms / chemistry, pathology*, radiography, surgery Male Neoplasm Proteins / analysis Neurofilament Proteins / analysis Paraganglioma / chemistry, pathology*, radiography, surgery Radiography, Thoracic S100 Proteins / analysis Synaptophysin / analysis Tomography, X-Ray Computed Tumor Markers, Biological / analysis |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/CAM 5.2 antigen; 0/Chromogranin A; 0/Chromogranins; 0/Neoplasm Proteins; 0/Neurofilament Proteins; 0/S100 Proteins; 0/Synaptophysin; 0/Tumor Markers, Biological; 108688-71-7/neurofilament protein H; 68238-35-7/Keratins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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