| Pulmonary functional outcome at one year of age in infants treated with natural porcine surfactant at birth. | |
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MedLine Citation:
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PMID: 1391266 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This prospective study was designed to assess pulmonary function (functional residual capacity, FRC; dynamic lung compliance, CLdyn; and total pulmonary resistance, RL) at 1 year of corrected age in infants with neonatal respiratory distress syndrome treated with natural porcine surfactant (Curosurf) (n = 13), as compared to nontreated control infants (n = 9). Values from 21 healthy infants of similar age served as reference. We found similar pulmonary dysfunction (decreased CLdyn, elevated RL) in both patient groups. These results suggest that surfactant replacement therapy does not affect pulmonary function at 1 year of age in infants who survive respiratory distress syndrome. |
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Authors:
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H Walti; M Boulé; G Moriette; J P Relier |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Biology of the neonate Volume: 61 Suppl 1 ISSN: 0006-3126 ISO Abbreviation: Biol. Neonate Publication Date: 1992 |
Date Detail:
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Created Date: 1992-11-18 Completed Date: 1992-11-18 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0247551 Medline TA: Biol Neonate Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 48-53 Citation Subset: IM |
Affiliation:
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Service de Médecine Néonatale, Hôpital Port-Royal, Paris, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Airway Resistance
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drug effects Biological Products* Follow-Up Studies Functional Residual Capacity / drug effects Humans Infant Infant, Low Birth Weight Infant, Newborn Lung / drug effects Lung Compliance / drug effects Phospholipids* Prospective Studies Pulmonary Surfactants / pharmacology* Respiratory Distress Syndrome, Newborn / drug therapy, mortality Respiratory Mechanics / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Biological Products; 0/Phospholipids; 0/Pulmonary Surfactants; 129069-19-8/poractant alfa |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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