Document Detail

Pulmonary function test: its correlation with pulmonary high-resolution computed tomography in patients with rheumatoid arthritis.
MedLine Citation:
PMID:  21499875     Owner:  NLM     Status:  MEDLINE    
Our objective was to try to evaluate lung affection and to correlate an easier and cheaper method with the high-resolution computed tomography (HRCT) findings in patients with RA. Thirty-six RA patients were selected for HRCT lung scan (twelve patients with altered pulmonary function test (PFT) and 24 with normal PFT). The American Thoracic Society criteria were followed for the pulmonary test. Clinical and laboratory variables were recorded. A statistical analysis was done by Kaplan-Meyer survival curve and ROC curve. When HRCT was evaluated in all patients, only sixteen had an HRCT normal and twenty patients showed some radiologic alteration under HRCT such as: pleural thickness, bronchiectasis, interstitial pattern, micro-nodules pattern, ground-glass opacity, and a reticular pattern. A logistic regression showed that methotrexate use, evolution of the disease (beta 0.018), and FEV1 (beta 0.89) were statistically associated with HRCT alterations. A projection of patients, free from event (HRCT lung scan altered), was obtained through a Kaplan-Meyer analysis, using FEV1 as a predictor over time. The curve shows that in the next 240 months (20 years) nearly 40% of the patients with rheumatoid arthritis will have FEV1 values less than 80% of the normal values predicted for the same age and sex. The FEV1 values have demonstrated a good correlation between PFT and HRCT lung scan. Therefore, they provide an accessible tool for tracking early pulmonary alterations. Methotrexate use and time evolution of the disease have been associated with altered FEV1.
Daza Leonel; Cervantes Lucia; Muñiz A; Hernández Martha-Alicia; Murillo Blanca
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Publication Detail:
Type:  Journal Article     Date:  2011-04-17
Journal Detail:
Title:  Rheumatology international     Volume:  32     ISSN:  1437-160X     ISO Abbreviation:  Rheumatol. Int.     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-06-26     Completed Date:  2012-11-21     Revised Date:  2013-01-11    
Medline Journal Info:
Nlm Unique ID:  8206885     Medline TA:  Rheumatol Int     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  2111-6     Citation Subset:  IM    
Clinical Research Department, Unidad Médica de Alta Especialidad No. 48, Instituto Mexicano del Seguro Social, Blvd. A. López Mateos e Insurgentes S/N, Col. Los Paraisos León Guanajuato, Mexico, CP 37480, USA.
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MeSH Terms
Antirheumatic Agents / therapeutic use
Arthritis, Rheumatoid / drug therapy,  radiography*
Bronchiectasis / physiopathology,  radiography
Lung / drug effects,  physiology,  radiography*
Methotrexate / therapeutic use
Middle Aged
Respiratory Function Tests / methods*
Tomography, X-Ray Computed / methods*
Treatment Outcome
Reg. No./Substance:
0/Antirheumatic Agents; 59-05-2/Methotrexate
Comment In:
Rheumatol Int. 2012 Nov;32(11):3703   [PMID:  22008997 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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