Document Detail


Pulmonary function and the risk of functional limitation in chronic obstructive pulmonary disease.
MedLine Citation:
PMID:  18343879     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The authors' objective was to analyze the impact of respiratory impairment on the risk of physical functional limitations among adults with chronic obstructive pulmonary disease (COPD). They hypothesized that greater pulmonary function decrement would result in a broad array of physical functional limitations involving organ systems remote from the lung, a key step in the pathway leading to overall disability. The authors used baseline data from the Function, Living, Outcomes, and Work (FLOW) study, a prospective cohort study of adults with COPD recruited from northern California in 2005-2007. They studied the impact of pulmonary function impairment on the risk of functional limitations using validated measures: lower extremity function (Short Physical Performance Battery), submaximal exercise performance (6-Minute Walk Test), standing balance (Functional Reach Test), skeletal muscle strength (manual muscle testing with dynamometry), and self-reported functional limitation (standardized item battery). Multiple variable analysis was used to control for confounding by age, sex, race, height, educational attainment, and cigarette smoking. Greater pulmonary function impairment, as evidenced by lower forced expiratory volume in 1 second (FEV(1)), was associated with poorer Short Physical Performance Battery scores and less distance walked during the 6-Minute Walk Test. Lower forced expiratory volume in 1 second was also associated with weaker muscle strength and with a greater risk of self-reported functional limitation (p < 0.05). In conclusion, pulmonary function impairment is associated with multiple manifestations of physical functional limitation among COPD patients. Longitudinal follow-up can delineate the impact of these functional limitations on the prospective risk of disability, guiding preventive strategies that could attenuate the disablement process.
Authors:
Mark D Eisner; Carlos Iribarren; Edward H Yelin; Stephen Sidney; Patricia P Katz; Lynn Ackerson; Phenius Lathon; Irina Tolstykh; Theodore Omachi; Nancy Byl; Paul D Blanc
Related Documents :
8520769 - The impact of exercise reconditioning on breathlessness in severe chronic airflow limit...
1576849 - Ventilatory and metabolic changes as a result of exercise training in copd patients.
11157589 - Distribution of muscle mass and maximal exercise performance in patients with copd.
3780329 - Effect of alprazolam on exercise and dyspnea in patients with chronic obstructive pulmo...
2280199 - Clinico-physiological status of thai copd patients.
16423209 - Maintaining exercise capacity and quality of life following pulmonary rehabilitation.
4018049 - Variations in iron status with fatigue modelled from training in female distance runners.
21555729 - Behavioral therapy to treat urinary incontinence in parkinson disease.
6700629 - Changes in fiber type composition in growing muscle as a result of dynamic exercise and...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2008-03-14
Journal Detail:
Title:  American journal of epidemiology     Volume:  167     ISSN:  1476-6256     ISO Abbreviation:  Am. J. Epidemiol.     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-04-28     Completed Date:  2008-05-08     Revised Date:  2014-09-18    
Medline Journal Info:
Nlm Unique ID:  7910653     Medline TA:  Am J Epidemiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1090-101     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Aged
California
Cross-Sectional Studies
Disability Evaluation*
Educational Status
Female
Humans
Interviews as Topic
Linear Models
Lung Volume Measurements
Male
Managed Care Programs
Middle Aged
Muscle Strength
Prospective Studies
Pulmonary Disease, Chronic Obstructive / classification,  physiopathology*
Spirometry
Grant Support
ID/Acronym/Agency:
R01 HL077618/HL/NHLBI NIH HHS; R01 HL077618-04/HL/NHLBI NIH HHS; R01HL077618/HL/NHLBI NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Incident diabetes and pesticide exposure among licensed pesticide applicators: Agricultural Health S...
Next Document:  Dietary boron and hormone replacement therapy as risk factors for lung cancer in women.