| Pulmonary function and histological impairment in mice after acute exposure to aluminum dust. | |
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MedLine Citation:
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PMID: 20545475 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Along the aluminum refining process, alumina (Al2O3) constitutes the main source of dust. Although aluminum refinery workers present respiratory symptoms with lung functional changes, no conclusive data about lung function impairment after alumina exposure has been so far reported. We examined the pulmonary alterations of exposure to material collected in an aluminum refinery in Brazil. BALB/c mice were exposed in a whole-body chamber for 1 h to either saline (CTRL, n = 11) or to a suspension (in saline) of 8 mg/m(3) of the dust (ALUM, n = 11) both delivered by an ultrasonic nebulizer. Twenty-four hours after exposure lung mechanics were measured by the end-inflation method. Lungs were prepared for histology. ALUM showed significantly higher static elastance (34.61 +/- 5.76 cmH2O/mL), elastic component of viscoelasticity (8.16 +/- 1.20 cmH2O/mL), pressure used to overcome the resistive component of viscoelasticity (1.62 +/- 0.24 cmH2O), and total resistive pressure (2.21 +/- 0.49 cmH2O) than CTRL (27.95 +/- 3.63 cmH2O/mL, 6.12 +/- 0.99 cmH2O/mL, 1.23 +/- 0.19 cmH2O, and 1.68 +/- 0.23 cmH2O, respectively). ALUM also presented significantly higher fraction area of alveolar collapse (69.7 +/- 1.2%) and influx of polymorphonuclear cells (27.5 +/- 1.1%) in lung parenchyma than CTRL (27.2 +/- 1.1% and 14.6 +/- 0.7%, respectively). The composition analysis of the particulate matter showed high concentrations of aluminum. For the first time it was demonstrated in an experimental model that an acute exposure to dust collected in an aluminum producing facility impaired lung mechanics that could be associated with inflammation. |
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Authors:
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Flavia Mazzoli-Rocha; Aline Nogueira Dos Santos; Silviane Fernandes; Valeria Marques Ferreira Normando; Olaf Malm; Paulo Hilário Nascimento Saldiva; Domingos Luiz Wanderley Picanço-Diniz; Débora Souza Faffe; Walter Araujo Zin |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Inhalation toxicology Volume: 22 ISSN: 1091-7691 ISO Abbreviation: Inhal Toxicol Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-08-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8910739 Medline TA: Inhal Toxicol Country: England |
Other Details:
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Languages: eng Pagination: 861-7 Citation Subset: IM |
Affiliation:
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Laboratory of Respiration Physiology, Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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