Document Detail

Pulmonary function after surfactant lung lavage followed by surfactant administration in infants with severe meconium aspiration syndrome.
MedLine Citation:
PMID:  15512724     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The effect of surfactant lung lavage (SLL) on pulmonary function was examined in neonates with severe form of meconium aspiration syndrome (MAS) (mean +/- standard deviation: birth weight, 3178.1 +/- 237.6 g; gestational age, 37.7 +/- 1.8 weeks). METHODS: The infants were on mechanical ventilation and were subjected to SLL with Survanta. Dynamic compliance (Cdyn), airway resistance (Raw) and mean airway pressure (MAP) were obtained with use of the pneumotachometric method. Measurements of Cdyn, Raw, MAP and time constant (Tc) were compared in the study and control groups and between the groups before SLL and 24 and 48 h after SLL. RESULTS: A significant increase in Cdyn (from 1.06 +/- 0.23 to 2.12 +/- 0.99 (ml/cmH(2)O)/kg) (p < 0.05) and a drop in both Raw (from 264.7 +/- 41.5 to 146.6 +/- 39.4 (cmH(2)O/l)/s) and MAP (from 12.4 +/- 3.6 to 5.4 +/- 2.1 cmH(2)O) were observed 48 hours after SLL. CONCLUSIONS: These data suggest that SLL is associated with a rapid and significant improvement in pulmonary mechanics, together with an improvement in oxygenation, in newborns with severe MAS. We found that the beneficial effects of SLL on pulmonary mechanics persisted for at least 48 h after introduction of the procedure.
M Szymankiewicz; J Gadzinowski; K Kowalska
Related Documents :
24729634 - Hearing versus listening: attention to speech and its role in language acquisition in d...
11407344 - Neonatal pulmonary hypertension--urea-cycle intermediates, nitric oxide production, and...
19554014 - Methemoglobin to cumulative nitric oxide ratio and response to inhaled nitric oxide in ...
7623244 - Nitric oxide reversal of recurrent pulmonary hypertension and respiratory failure in an...
7629954 - The effect of zinc supplementation on pregnancy outcome.
24736004 - Breast milk and group b streptococcal infection: vector of transmission or vehicle for ...
Publication Detail:
Type:  Evaluation Studies; Journal Article    
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  16     ISSN:  1476-7058     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-10-29     Completed Date:  2005-03-03     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  125-30     Citation Subset:  IM    
Department of Neonatology, University of Medical Sciences, Poznań, Poland.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Bronchoalveolar Lavage / methods*
Case-Control Studies
Infant, Newborn
Meconium Aspiration Syndrome / pathology,  therapy*
Pulmonary Surfactants / administration & dosage,  therapeutic use*
Respiration, Artificial
Respiratory Function Tests
Severity of Illness Index
Reg. No./Substance:
0/Pulmonary Surfactants

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The effects of veno-venous extracorporeal membrane oxygenation on hypoxic fetal lambs.
Next Document:  Uterine artery Doppler and mid-trimester maternal plasma homocysteine in subsequent pre-eclampsia.